PTGER4
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Official Full Name
prostaglandin E receptor 4 (subtype EP4) -
Overview
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008] -
Synonyms
PTGER4;prostaglandin E receptor 4 (subtype EP4);EP4;EP4R;prostaglandin E2 receptor EP4 subtype;prostanoid EP4 receptor;PGE receptor EP4 subtype;PGE receptor, EP4 subtype;PGE2 receptor EP4 subtype
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- Pan troglodytes
- Bovine
- Mus musculus
- Oryctolagus cuniculus (Rabbit)
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- E.coli expression system
- His
- Non
- His&Flag
- His&GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PTGER4 involved in several pathways and played different roles in them. We selected most pathways PTGER4 participated on our site, such as Neuroactive ligand-receptor interaction,Inflammatory mediator regulation of TRP channels,Renin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGER4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renin secretion | GNAI1,PDE1B,PLCB2,NPR1,CALM4,GNAS,PLCB3,AQP1,ACE,CLCA5 |
| Neuroactive ligand-receptor interaction | P2RY2,OPRL1,ADRB2B,ADRB2A,TAAR14H,NPFFR1,GRM6,TAAR10C,CHRNB1,GLP1R |
| Inflammatory mediator regulation of TRP channels | ALOX12,TRPA1,Adcy4,BDKRB1,PIK3R5,CYP2C37,CYP2J6,CALM2,PRKACG,CALML5 |
| Pathways in cancer | SMAD4,APPL1,Adcy4,APC,WNT9B,PRKCG,GLI2,GSTP1,FGF21,WNT5B |
Protein Function
PTGER4 has several biochemical functions, for example, prostaglandin E receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGER4 itself. We selected most functions PTGER4 had, and list some proteins which have the same functions with PTGER4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| prostaglandin E receptor activity | PTGER4A,PTGER2,PTGER1,PTGER2A,HPGD,PTGER2B,PTGER3,PTGER1B,PTGER1C,PTGER1A |
| protein binding | SLC22A7,HPS6,TTC8,FCN2,ASAP3,PDCD2,MGST1,LRRC29,TTC3,MYOG |
Interacting Protein
PTGER4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGER4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGER4.
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