PTBP1
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Official Full Name
polypyrimidine tract binding protein 1 -
Overview
Polypyrimidine tract-binding protein is an RNA-binding protein, also known as PTB or hnRNP I. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described -
Synonyms
PTBP1;polypyrimidine tract binding protein 1;polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) , PTB;polypyrimidine tract-binding protein 1;heterogeneous nuclear ribonucleoprotein I;HNRNP I;HNRPI;pPTB;PTB 1;PTB2;PT
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- C-hFc-Myc
- Myc&DDK
- Flag
Involved Pathway
PTBP1 involved in several pathways and played different roles in them. We selected most pathways PTBP1 participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA,mRNA Splicing, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA processing | SFSWAP,PPM1G,HNRNPD,ADAM5,RBM12B1,PTBP2,HNRNPH1,RPL36A-HNRNPH2,RNASET2B,RBM12B2 |
| mRNA Splicing - Major Pathway | HNRNPL2,SUGP1,HNRNPA2B1,YBX1,HNRPL,SF3B4,BCAS2,HNRNPA0B,HNRNPA0A,RBM5 |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPL,DNAJC8,HNRNPA2B1,PAPOLA,METTL3,RNPC3,WTAP,HNRNPUL1,ZMAT5,SNRNP25 |
| Gene Expression | TARBP2,HNRNPR,ZNF75D,SAP30,ZNF257,RARAB,HNRNPD,WTAP,TAF1C,SAP30L |
| mRNA Splicing | CD2BP2,PTBP1A,RNPC3,PTBP1B,HNRNPH1L,DNAJC8,HNRNPA0B,HNRNPD,HNRNPL,SF3A3 |
Protein Function
PTBP1 has several biochemical functions, for example, RNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTBP1 itself. We selected most functions PTBP1 had, and list some proteins which have the same functions with PTBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TNIP2,USP10,SREK1IP1,FAM72A,KANSL2,TIMM50,CTSZ,ANTXR1,CDC25A,ICAM5 |
| RNA binding | SRSF10,A1CF,ENDOU,NPM1,ATXN2,RBM4,CSTF1,EXOSC6,IFIT11,DDX3Y |
| poly-pyrimidine tract binding | CPEB2,U2AF2 |
| pre-mRNA binding | TARBP2,RBM22,SRSF2,DDX5 |
| nucleotide binding | RBM4.1,PABPC1L,DCLK3,PKN1B,INSRA,LMTK2,TRA2A,CKMB,ABCC5,MTHFSD |
| poly(A) RNA binding | EIF4E2,NSUN2,PRDX1,Api5,SAMSN1,TRMT10C,ZCCHC17,DDX21,CCT4,ZC3H8 |
Interacting Protein
PTBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTBP1.
SNRPA;SFPQ;hnrnpab;QKI;ZMYM2
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