PSMD14
-
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -
Overview
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes;the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap;complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on;the long arm of chromosome 2. -
Synonyms
PSMD14;proteasome (prosome, macropain) 26S subunit, non-ATPase, 14;26S proteasome non-ATPase regulatory subunit 14;pad1;POH1;Rpn11;26S proteasome regulatory subunit rpn11;26S proteasome-associated PAD1 homolog 1
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- Cynomolgus
- Mouse
- Sf9 Insect Cell
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- GST
- His
- Non
- His&MBP
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PSMD14 involved in several pathways and played different roles in them. We selected most pathways PSMD14 participated on our site, such as APC/C-mediated degradation of cell cycle proteins,APC/C:Cdc20 mediated degradation of Securin,APC/C:Cdc20 mediated degradation of mitotic proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | PSMD10,PSMA8,PSMD9,UBE2C,PSME3,ANAPC10,NEK2,PSMD5 |
| AUF1 (hnRNP D0) binds and destabilizes mRNA | PSME3,PSMD10,PSMD9,PSMD5,HNRNPD,PSMA8,EIF4G1 |
| ARMS-mediated activation | FRS3,DUSP1,FRS2B,PSMA8,AKAP9,EGF,KBTBD7,CRK,JAK3,SPTBN2 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | ANAPC10,PSMD9,PSMA8,NEK2,PSMD5,PSME3,UBE2C,PSMD10 |
| APC/C:Cdc20 mediated degradation of Securin | ANAPC10,PSMD10,PSMD9,UBE2C,PSMD5,PSMA8,PSME3 |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | PSMD10,ANAPC10,UBE2C,AURKB,PSMD9,PSME3,PSMD5,PSMA8 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | PSMD10,ANAPC10,PSMA8,PSMD9,PSME3,UBE2C,PSMD5,NEK2 |
| APC/C-mediated degradation of cell cycle proteins | AURKB,NEK2,PSME3,CDK2,PSMD5,PSMD10,PSMA8,PSMD9,UBE2C,ANAPC10 |
Protein Function
PSMD14 has several biochemical functions, for example, endopeptidase activator activity,metal ion binding,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD14 itself. We selected most functions PSMD14 had, and list some proteins which have the same functions with PSMD14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| proteasome binding | UCHL5,USP14,UBD,ID1,USP13,PSMF1,PSMG1,ADRM1,BAG6,DNAJB2 |
| metallopeptidase activity | NPSN,PAPLNB,ADAM10A,DPEP3,ADAMTSL1,ADAMTSL3,ADAM23,BMP1,COPS5,Npepo |
| protein binding | DCD,GGA3,HIF1A,AP3S1,PAPD4,KIF3B,MMS19,STAU2,TRIM29,UBL4A |
| endopeptidase activator activity | ADRM1,PSME1,PSME2,SFRP2,PSME3 |
| metal ion binding | AMPD2,GDE1,CHAMP1,COX4I2,ZNF436,ITGA2,GNA13,FHL1B,TIMM8B,SMYD1 |
Interacting Protein
PSMD14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD14 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD14.
PSMD7;PSMD6;UCHL5;MEOX2;PSMD11;PSMD12
Resources
Related Services
Related Products
References
