PSMD13
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Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. -
Synonyms
PSMD13;proteasome (prosome, macropain) 26S subunit, non-ATPase, 13;26S proteasome non-ATPase regulatory subunit 13;p40.5;Rpn9;26S proteasome non ATPase regulatory subunit 13;26S proteasome regulatory subunit S11;S11;26S proteasome subunit p40.5;26S proteasome regulatory subunit RPN9;26S proteasome regulatory subunit p40.5;HSPC027
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PSMD13 involved in several pathways and played different roles in them. We selected most pathways PSMD13 participated on our site, such as Proteasome,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMD11A,PSMC1B,PSMB10,PSMB3,PSMD6,PSMB1,PSMD12,PSMB9,PSME2,PSMC1A |
| Epstein-Barr virus infection | HLA-DQB1,CD44,POLR2F,IFNG,HDAC1,PIK3R3,HDAC2,NFKB1,POLR2K,POLR2E |
Protein Function
PSMD13 has several biochemical functions, for example, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD13 itself. We selected most functions PSMD13 had, and list some proteins which have the same functions with PSMD13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | IFFO2,MAP2,LAMA3,KRT28,SEPT5,CLDNI,CLDN15LB,NUMA1,MPZL1,KRT83 |
Interacting Protein
PSMD13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD13 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD13.
PSMD4;TRAF6;PSMD14;PSMC1;UCHL5;NFKB2;51464989;PSMD11;PSMD12;PSMA7;PSMD3;EIF1B;GH1;FES
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References
- Li, SH; Izumi, T; et al. Rescue of Enzymatic Function for Disease-associated RPE65 Proteins Containing Various Missense Mutations in Non-active Sites. JOURNAL OF BIOLOGICAL CHEMISTRY 289:18943-18956(2014).
- Bi, W; Zhu, LH; et al. Investigations into the Role of 26S Proteasome Non-ATPase Regulatory Subunit 13 in Neuroinflammation. NEUROIMMUNOMODULATION 21:331-337(2014).
