PSMB10
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Official Full Name
proteasome (prosome, macropain) subunit, beta type, 10 -
Overview
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. -
Synonyms
PSMB10;proteasome (prosome, macropain) subunit, beta type, 10;MECL1;proteasome subunit beta type-10;beta2i;LMP10;MGC1665;FLJ00366;Low molecular mass protein 10;Macropain subunit MECl 1;Macropain subunit MECl-1;Multicatalytic endopeptidase complex subunit MECl 1;Multicatalytic endopeptidase complex subunit MECl-1;OTTHUMP00000174858;Proteasome (prosome macropain) subunit beta type 10;Proteasome beta 10 subunit;Proteasome catalytic subunit 2i;Proteasome MECl 1;Proteasome MECl-1;Proteasome subunit beta 2i;Proteasome subunit beta 7i;Proteasome subunit beta type 10;Proteasome subunit beta-2i;Proteasome subunit MECL1;PSB10_HUMAN;PSMB 10;multicatalytic endop
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
PSMB10 involved in several pathways and played different roles in them. We selected most pathways PSMB10 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMB10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMA5,PSMC3,PSMB6,PSMC2,PSMA6A,PSMA4,PSMA1,IFNG,PSMD3,PSMC6 |
Protein Function
PSMB10 has several biochemical functions, for example, endopeptidase activity,protein binding,threonine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMB10 itself. We selected most functions PSMB10 had, and list some proteins which have the same functions with PSMB10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | MMP1A,KLK1B4,APH1B,KLK1B16,PSMB9,CPS1,KLK1B24,PSMB9B,MMP3,ATG4B |
| threonine-type endopeptidase activity | PSMB9A,PSMB11,PSMB9,PSMA4,PSMA7,PSMB4,PSMB1,PSMA5,PSMA3,PSMB8 |
| protein binding | TXNDC5,KRTAP4-11,ENC1,BBS4,IRAK4,LBP,NEK1,EEA1,SLC1A5,CPT1C |
Interacting Protein
PSMB10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMB10 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMB10.
CCNDBP1;MEOX2;CRX;ANXA7;PTN;PSMA1;PSMB3;PSMA2;MYH9;PSMB7
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