PSMA2
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Official Full Name
proteasome (prosome, macropain) subunit, alpha type, 2 -
Overview
The proteasome is widely recognised as the central enzyme of non lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. The 26S proteasome is the key enzyme of the ubiquitin/ATP dependent pathway of protein degradation. The catalytic core of this unusually large complex is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. Based on sequence similarity, all fourteen 20S proteasomal subunit sequences may be classified into two groups, alpha and beta, each group having distinct structural and functional roles. The alpha subunits comprise the outer rings and the beta subunits the inner rings of the 20S proteasome. Observations of the eukaryotic proteasome and analysis of subunit sequences indicate that each ring contains seven different subunits (alpha7/beta7/beta7/alpha7) with a member of each sub family represented in each particle. Each subunit is located in a unique position within the alpha or beta rings. 20S Proteasomes degrade only unfolded proteins in an energy independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome. -
Synonyms
PSMA2;proteasome (prosome, macropain) subunit, alpha type, 2;proteasome subunit alpha type-2;HC3;MU;PMSA2;macropain subunit C3;proteasome subunit HC3;proteasome component C3;multicatalytic endopeptidase complex subunit C3;PSC2
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
PSMA2 involved in several pathways and played different roles in them. We selected most pathways PSMA2 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMB9,IFNG,PSMF1,PSMD2,PSMB3,PSMA4,PSMB5,PSMD11A,PSMC1B,PSMB2 |
Protein Function
PSMA2 has several biochemical functions, for example, endopeptidase activity,protein binding,threonine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMA2 itself. We selected most functions PSMA2 had, and list some proteins which have the same functions with PSMA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| threonine-type endopeptidase activity | PSMA6,PRSS50,PSMB1,PSMB9B,PSMA6A,PSMB7,PSMB6,PSMB4,PSMA8,PSMA6B |
| protein binding | C19orf80,OPA1,HYI,LGR4,RHOB,ENTPD1,F12,PRRG2,UBA7,WIPF1 |
| endopeptidase activity | MMP3,PSMB9A,PSMA3,SENP5,PSMA8,SENP3B,PSMB4,PSMB8F,PSMB2,KLK1B22 |
Interacting Protein
PSMA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMA2.
PSMA4;PSMA1;PSMA7;PSMA6
Resources
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References
- Olausson, KH; Maire, CL; et al. Prominin-1 (CD133) Defines Both Stem and Non-Stem Cell Populations in CNS Development and Gliomas. PLOS ONE 9:-(2014).
- Karbanova, J; Laco, J; et al. Human PROMININ-1 (CD133) Is Detected in Both Neoplastic and Non-Neoplastic Salivary Gland Diseases and Released into Saliva in a Ubiquitinated Form. PLOS ONE 9:-(2014).
