PSEN1

  • Product List
  • Overview
  • Review / Q&A

  • Official Full Name

    presenilin 1

  • Overview

    Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

  • Synonyms

    PSEN1;presenilin 1;AD3;FAD;PS1;PS-1;S182;presenilin-1

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Rat
  • Chicken
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • His
  • Non
  • Flag
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PSEN1-2004H Recombinant Human PSEN1 Protein, His-tagged E.coli Human His 254-377aa
PSEN1-13545M Recombinant Mouse PSEN1 Protein Mammalian Cells Mouse His
PSEN1-29963TH Recombinant Human PSEN1 Wheat Germ Human Non 100 amino acids
PSEN1-3643R Recombinant Rhesus monkey PSEN1 Protein, His-tagged Mammalian Cells Rhesus macaque His
PSEN1-4758R Recombinant Rat PSEN1 Protein Mammalian Cells Rat His
PSEN1-5738C Recombinant Chicken PSEN1 Mammalian Cells Chicken His
PSEN1-8653Z Recombinant Zebrafish PSEN1 Mammalian Cells Zebrafish His
PSEN1-2790HCL Recombinant Human PSEN1 293 Cell Lysate HEK293 Human Non
PSEN1-23HFL Recombinant Full Length Human presenilin 1 Protein, Flag tagged HEK293 Human Flag Full L. 1-467aa
PSEN1-313H Recombinant Human PSEN1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
PSEN1-3461R Recombinant Rhesus Macaque PSEN1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
PSEN1-3461R-B Recombinant Rhesus Macaque PSEN1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PSEN1-4417R Recombinant Rat PSEN1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
PSEN1-4417R-B Recombinant Rat PSEN1 Protein Pre-coupled Magnetic Beads HEK293 Rat
Psen1-5171M Recombinant Mouse Psen1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
PSEN1-7201M Recombinant Mouse PSEN1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
PSEN1-7201M-B Recombinant Mouse PSEN1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

Involved Pathway

PSEN1 involved in several pathways and played different roles in them. We selected most pathways PSEN1 participated on our site, such as Wnt signaling pathway,Notch signaling pathway,Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSEN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathway CAMK2G,WNT9A,DAAM2,SFRP2,ROCK2A,FZD1,BAMBIB,FBXW11,SFRP1A,CACYBP
Neurotrophin signaling pathway PSEN2,CALM4,RAC1,AKT2,IKBKB,NFKBIA,GSK3B,SOS1,MAPK12,GRB2
Alzheimers disease COX7A1,ATP5J,NDUFC2,ITPR2,BACE1,CASP9,NDUFA6,GAPDH,ATP5F1,ATP5D
Notch signaling pathway MFAP2,YY1,TLE3A,RBPJL,NOTCH4,DLA,HER15.1,CTBP2,HER12,EP300

Protein Function

PSEN1 has several biochemical functions, for example, PDZ domain binding,aspartic-type endopeptidase activity,beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSEN1 itself. We selected most functions PSEN1 had, and list some proteins which have the same functions with PSEN1. You can find most of the proteins on our site.

Function Related Protein
aspartic-type endopeptidase activity ANK2B,PIP,BACE1,NOTS,Casp3,ASPRV1,REN,PSEN2,PGA5,NRIP2
protein binding XPA,RRAGD,STATH,DYRK2,CSRNP1,DCSTAMP,KIFC3,SH2D4A,RPA2,GUCY1B3
calcium channel activity CHRNA10,TRPC3,PKD2L2,GPM6A,TRPV6,TRPC5,TMEM37,TRPM4,CACNG1A,TRPM6
beta-catenin binding DACT3,KDM6B,CD2AP,BTRC,CTNNBIP1,CDH1,CHD8,AXIN1,APC2,BCL9L
cadherin binding PTPRM,FER,OLFM4,VCL,AKAP5,JUPA,MMP24,Fert2,NDRG1,JUP
PDZ domain binding SLC22A5,FZD3,FZD8,ATP2B1,GIPC1,ARHGAP29,CLCN3,ACVR2A,ADRB1,ATP2B2
endopeptidase activity MME,CD46,REN2,MMP9,PSMA8,CTSH,KLK1B22,PSMB11,SENP1,SENP3A

Interacting Protein

PSEN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSEN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSEN1.

APBA1;NCSTN;APP;JUP;PKP4

PSEN1 Related Signal Pathway

Resources

Research Area

Notch Pathway
Notch Family
Alzheimer's Disease
E-Cadherin Ectodomain Shedding and Proteolytic Processing

References

  • Reinert, J; Martens, H; et al. A beta(38) in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models. JOURNAL OF ALZHEIMERS DISEASE 39:871-881(2014).
  • Irwin, DJ; Cohen, TJ; et al. Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies. AMERICAN JOURNAL OF PATHOLOGY 183:344-351(2013).

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