PRKX
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Official Full Name
protein kinase, X-linked -
Overview
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. -
Synonyms
PRKX;protein kinase, X-linked;cAMP-dependent protein kinase catalytic subunit PRKX;PKX1;protein kinase X;protein kinase PKX1;protein kinase X-linked;serine/threonine-protein kinase PRKX
Recombinant Proteins
- Human
- Rat
- Mouse
- Rhesus macaque
- E.coli
- Sf9 Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- Insect Cells
- Sf21 Cells
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PRKX involved in several pathways and played different roles in them. We selected most pathways PRKX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PRKX has several biochemical functions, for example, ATP binding,cAMP-dependent protein kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKX itself. We selected most functions PRKX had, and list some proteins which have the same functions with PRKX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM54B,POLR2E,TEX14,PPP1R2P3,ACACB,ARPC2,LRRC3,MYEF2,TH1L,F11 |
| cAMP-dependent protein kinase activity | PRKAA1,PRKACG,PRKACA,PRKAG1,AKAP13,PRKACB |
| ATP binding | ALPK1,CSNK1D,MINK1,NTRK1,MAPK10,MYH1B,ABCF3,AURKC,PKDCC,DHX16 |
Interacting Protein
PRKX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKX here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKX.
SMAD6;HSP90AB1;PRKAR1A;GPKOW;N/A;Prkacb
Resources
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References
- Bender, C; Ullrich, A; et al. PRKX, TTBK2 and RSK4 expression causes sunitinib resistance in kidney carcinoma- and melanoma-cell lines. INTERNATIONAL JOURNAL OF CANCER 131:E45-E55(2012).
- Li, W; Yu, ZX; et al. Profiles of PrKX expression in developmental mouse embryo and human tissues. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 53:1003-1009(2005).
- MARINO, IR; CELLI, S; et al. ANTIBODY-BINDING TO ENDOTHELIAL AND EPITHELIAL ANTIGENS TRIGGERS PIG-TO-RABBIT XENOGRAFT REJECTION AND ITS ABSENCE RESULTS IN ATYPICAL COMPLEMENT DEPOSITION. TRANSPLANT INTERNATIONAL 5:S320-S322(1992).
