PRKD1
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Official Full Name
protein kinase D1 -
Overview
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor;signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and;regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 (PubMed 19329994)). -
Synonyms
PRKD1;protein kinase D1;PRKCM, protein kinase C, mu;serine/threonine-protein kinase D1;PKC mu;PKCM;PKD;nPKC-D1;nPKC-mu;protein kinase D;protein kinase C, mu;protein kinase C mu type;PRKCM;PKC-MU
Recombinant Proteins
- Mouse
- Human
- Chicken
- Mammalian Cell
- E.coli
- Sf9 Insect Cell
- HEK293
- Insect Cell
- Insect (sf21)
- HEK293T
- His
- His&T7
- Non
- GST
- His&GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PRKD1 involved in several pathways and played different roles in them. We selected most pathways PRKD1 participated on our site, such as Rap signaling pathway,Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone synthesis and secretion | CYP11B2,SCARB1,CALM1,ATF6B,ADCY1,HSD3B6,ITPR3,AKR1C1,CREB3L4,CAMK2G |
| Rap signaling pathway | Kitl,MAP2K2,VEGFB,INS,PIK3CB,FGF21,RAPGEF6,LCP2,PIK3R3,FGF4 |
Protein Function
PRKD1 has several biochemical functions, for example, ATP binding,identical protein binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKD1 itself. We selected most functions PRKD1 had, and list some proteins which have the same functions with PRKD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZFP458,HPX,FGD1,CACNA1H,FTR14,TRIM35-39,PCCA,TRIM35-36,ASH2L,MSS51 |
| protein binding | TSG101,CAMK2G,VPS29,MRE11A,AAK1,LIN9,BCAS2,CDC14B,ARPC3,HNRPLL |
| protein kinase C activity | PRKD3,PKN1,PRKCBB,PRKCA,PRKCH,PKN3,PRKCDA,PRKCBA,PKN2,PRKCHB |
| identical protein binding | CIDEB,KHDRBS1,CCDC109A,SH3BP4,EPOR,DAPK3,ACTG1,FADD,PHC2,DDX58 |
| ATP binding | GATC,G3BP1,FKBP4,EPHA7,BTK,ATP2B2,YME1L1,VPS4B,UBE2QL1,DGKG |
| protein serine/threonine kinase activity | PRKCBB,SRPK1,MYO3A,CSNK1E,STK36,ULK1A,CAMKK1A,STK33,CSNK1DB,SBK1 |
Interacting Protein
PRKD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKD1.
C1QBP;N/A;MAPK13;MT2A
Resources
Research Area
Calcium-binding Proteins and Related MoleculesIntracellular Signaling Molecules in Angiogenesis
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References
- Sidhu, PS; Teske, K; et al. Anticancer activity of VDR-coregulator inhibitor PS121912. CANCER CHEMOTHERAPY AND PHARMACOLOGY 74:787-798(2014).
- Du, X; Li, YM; et al. Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:1559-1564(2014).
