PRKACA
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Official Full Name
protein kinase, cAMP-dependent, catalytic, alpha -
Overview
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the;cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The;inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the;dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric;catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans.;The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of;cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been;observed. -
Synonyms
PRKACA;protein kinase, cAMP-dependent, catalytic, alpha;cAMP-dependent protein kinase catalytic subunit alpha;PKACa;PKA C-alpha;protein kinase A catalytic subunit;cAMP-dependent protein kinase catalytic subunit alpha, isoform 1;MGC48865;MGC102831
Recombinant Proteins
- Human
- Canine
- Mouse
- Dog
- E.coli
- Insect Cells
- Sf9 Cells
- N-His
- Mammalian Cells
- HEK293
- Sf21 Cells
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
PRKACA involved in several pathways and played different roles in them. We selected most pathways PRKACA participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cholinergic synapse | GNG4,GNGT2,CAMK2G,KCNJ6,PRKACB,GNG3,GNAI2,ITPR1,GNG7,GNGT1 |
| Insulin secretion | INS1,PRKACB,FXYD2,KCNN3,ADCYAP1,SLC2A1,PLCB1,PCLO,SLC2A2,INS2 |
| Dilated cardiomyopathy | CACNA2D2,ITGA9,ITGA1,ITGA8,CACNG4,ATP2A2,ITGB3,TNNI3,ITGA10,MYL2 |
| Thyroid hormone synthesis | ATF4,CREB3L2,ATP1B2,GPX5,TTF2,GPX6,ASGR1,ATP1B1,GNAS,GNAQ |
| Alcoholism | GRIN2B,GRIN3B,CREB3L4,HIST1H3A,H3F3B,GNG8,GRB2,GNG7,KRAS,HDAC6 |
| Viral carcinogenesis | HIST1H2BP,UBE3A,TBPL1,RHOA,CDC42,TBP,PIK3CA,RBL1,GTF2B,HIST1H2BQ |
| Glutamatergic synapse | GRIA3,GNAS,SLC1A7,GNB1,PLCB3,GRIN2B,GRIA4,GRIN2D,GRIK3,SLC38A2 |
| Retrograde endocannabinoid signaling | GABRG3,MAPK13,PLCB2,GRIA3,MAPK3,GNGT1,MAPK9,GNG12,ITPR1,GABRA5 |
| Inflammatory mediator regulation of TRP channels | ASIC5,TRPV3,PTGER2,IGF1,Adcy4,PLA2G4A,PLCB3,PIK3R5,PLCG2,CALM2 |
Protein Function
PRKACA has several biochemical functions, for example, ATP binding,cAMP-dependent protein kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACA itself. We selected most functions PRKACA had, and list some proteins which have the same functions with PRKACA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CPSF6,ASIC1,NXT2,MMP9,LRP4,KIAA1143,RIPK4,TTC5,EHD2,PLK3 |
| ubiquitin protein ligase binding | TMEM173,GPI1,UBE2KB,SUMO2,PIAS1,MAGEC2,UBE2G1,TANK,UBE2G1A,HSPA1A |
| cAMP-dependent protein kinase activity | AKAP13,PRKAA1,PRKX,PRKAG1,PRKACB,PRKACG |
| protein kinase binding | RPS3,SCN5A,CACNB4,RNF138,TBC1D14,MAPK4,PLCG1,ELP2,PARN,BAD |
| protein kinase A regulatory subunit binding | ARFGEF1,C2orf88,ARFGEF2,AKAP6,AKAP9,AKAP1,KCNQ1,RYR2,ACBD3,AKAP5 |
| protein serine/threonine/tyrosine kinase activity | CLK1,TESK2,AURKC,MAP2K1,TESK1,RPS6KA2,DYRK1B,ACVR2B,AURKA,CLK3 |
| protein complex binding | PPP2R2A,MYC,CPD,NRAS,TUBB,C8A,RANBP2,Ctsl,TULP3,SREBF1 |
| ATP binding | ZAP70,PTK6B,CKMT1B,KIAA1804,PIM1,DSTYK,HLCS,TARS,CKMT2,SARS |
Interacting Protein
PRKACA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACA here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACA.
PRKAR1A;PRKAR2B;GSK3B;PRKAR2A;PRKAR1B;LRRK2
Resources
Research Area
Apoptosis Intracellular KinasesIntracellular Kinases in the Akt Pathway
ROS and Stress Resistance
PKA Isoforms
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References
