PRG2
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Official Full Name
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -
Overview
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PRG2;proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein);MBP;BMPG;MBP1;bone marrow proteoglycan;bone-marrow proteoglycan;proteoglycan 2 preproprotein;natural killer cell activator;eosinophil major basic protein;eosinophil granule major basic protein;prg-2;Piwi (fruitfly) Related Gene;Piwi (fruitfly) Related Gene family member (prg-2);4H292;tag-292
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Wheat Germ
- Human Cell
- Mammalian cells
- His&MBP
- His&GST
- His
- GST
- StrepII
- Non
- His&ABP
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PRG2-1745H | Recombinant Human PRG2 protein, His & MBP-tagged | E.coli | Human | His&MBP | Gln105~Tyr222 |
|
| Prg2-1746M | Recombinant Mouse Prg2 protein, His & GST-tagged | E.coli | Mouse | His&GST | Arg37~Lys215 |
|
| Prg2-1747R | Recombinant Rat Prg2 protein, His & GST-tagged | E.coli | Rat | His&GST | Gly80~Lys219 |
|
| PRG2-44H | Recombinant Human PRG2, His-tagged | HEK293 | Human | His | 17-222 a.a. |
|
| PRG2-45H | Recombinant Human PRG2, GST-tagged | Wheat Germ | Human | GST | 123-222 a.a. |
|
| PRG2-46H | Recombinant Human PRG2, StrepII-tagged | Human Cell | Human | StrepII | 17-222 a.a. |
|
| PRG2-2872HCL | Recombinant Human PRG2 293 Cell Lysate | HEK293 | Human | Non |
|
|
| PRG2-1264H | Recombinant Human PRG2 Protein (Leu17-Tyr222), C-His tagged | Mammalian cells | Human | His | Leu17-Tyr222 |
|
| PRG2-13H | Recombinant Human PRG2 Protein (Leu17-End), N-His-ABP tagged | E.coli | Human | His&ABP | Leu17-End |
|
| PRG2-1749H | Recombinant Human PRG2 Protein, His-GST-tagged | E.coli | Human | His&GST | 105-222 a.a. |
|
| PRG2-19H | Recombinant Human PRG2 Protein (Leu17-End), N-His-ABP tagged | E.coli | Human | His&ABP | Leu17-End |
|
| PRG2-2390H | Recombinant Human PRG2 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 106-222aa |
|
| PRG2-4492H | Recombinant Human PRG2 protein, His-GST-tagged | E.coli | Human | His&GST | 17-104aa |
|
| PRG2-5978H | Recombinant Human PRG2 Protein (Thr106-Tyr222), N-His tagged | E.coli | Human | His | Thr106-Tyr222 |
|
Involved Pathway
PRG2 involved in several pathways and played different roles in them. We selected most pathways PRG2 participated on our site, such as Asthma, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Asthma | HLA-DRB3,IL3,IL4,IL5,FCER1G,TNF,HLA-DPB1,HLA-DQB1,MS4A2,H2-AB1 |
Protein Function
PRG2 has several biochemical functions, for example, carbohydrate binding,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRG2 itself. We selected most functions PRG2 had, and list some proteins which have the same functions with PRG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | APOB,F11,RPL29,APPA,PF4,FGF12,LPL,CXCL6,OGN,THBS3 |
| carbohydrate binding | SIGLEC12,GALNT10,KLRC4-KLRK1,SBP,CLEC4D,CLEC4A,CD33,PKD1L2,LGALS2,EMC7 |
Interacting Protein
PRG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRG2.
CHD3;RBM48
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