PRDX5
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Official Full Name
peroxiredoxin 5 -
Overview
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
PRDX5;peroxiredoxin 5;peroxiredoxin-5, mitochondrial;ACR1;Alu co repressor 1;antioxidant enzyme B166;AOEB166;B166;liver tissue 2D page spot 71B;MGC117264;MGC142283;MGC142285;peroxisomal antioxidant enzyme;PLP;PMP20;PRDX6;PRXV;SBBI10;thio
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- E. coli
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PRDX5 involved in several pathways and played different roles in them. We selected most pathways PRDX5 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | BAAT,PEX12,ACSL1,ACSL4B,PEX14,CRAT,AMACR,NUDT12,SLC27A2,NUDT19 |
Protein Function
PRDX5 has several biochemical functions, for example, RNA polymerase III regulatory region DNA binding,antioxidant activity,cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX5 itself. We selected most functions PRDX5 had, and list some proteins which have the same functions with PRDX5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peroxidase activity | PTGS2,GPX8,PTGS2A,PTGS1,PRDX1,GPX6,MGST3,MPO,GPX7,GPX1A |
| protein dimerization activity | ARNTL,POLR1D,TWIST1B,ZBED6,HER7,FIGLA,NEUROD4,ASCL3,STAT3,POLR2C |
| peroxiredoxin activity | PARK7,PRDX6 |
| receptor binding | WNT5B,FGF6A,NPPA,LAMA3,NMU,RARRES2,PTK2BB,CADM1B,FZD8,C1QTNF2 |
| antioxidant activity | CAT,APOM,FABP1,KDM3B,PRDX6,APOA4,PRDX2,HP,APOE,SELS |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | XIAP,SERPINB1A,TNFSF14,PRDX3,ARRB1,MT3,CD27,SERPINB9,BIRC2,C1QL4L |
Interacting Protein
PRDX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX5.
IKBKE;PINX1;BABAM1;CCDC90B;ATF2;ICT1;LIN54;SIRT4
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