PRDM14

  • Official Full Name

    PR domain containing 14

  • Overview

    This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional;regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell;pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in;breast cancer.

  • Synonyms

    PRDM14;PR domain containing 14;PR domain zinc finger protein 14;PR domain-containing protein 14;PFM11;MGC59730

Recombinant Proteins

  • Mouse
  • Human
  • Zebrafish
  • Mammalian Cells
  • Sf9 Cells
  • E.coli
  • HEK293
  • His
  • Flag
  • His&GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PRDM14-13314M Recombinant Mouse PRDM14 Protein Mammalian Cells Mouse His
PRDM14-66H Recombinant Human PRDM14, FLAG-tagged Sf9 Cells Human Flag
PRDM14-7561Z Recombinant Zebrafish PRDM14 Mammalian Cells Zebrafish His
PRDM14-1486H Recombinant Human PRDM14 protein, His & GST-tagged E.coli Human His&GST Glu395~His568
PRDM14-2912H Recombinant Human PRDM14 Protein, His-tagged E.coli Human His
PRDM14-7066M Recombinant Mouse PRDM14 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PRDM14-7066M-B Recombinant Mouse PRDM14 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PRDM14 involved in several pathways and played different roles in them. We selected most pathways PRDM14 participated on our site, such as Developmental Biology,Transcriptional regulation of pluripotent stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDM14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional regulation of pluripotent stem cells NR6A1,LIN28A,POU5F3,TDGF1,HIF3A,NR5A1,FOXD3,SALL4
    Developmental Biology DUSP2,SCN2B,NR6A1,LGI4,PTPRA,NRG2A,CACNG8A,ACTR3,EFNB3,TCF3A

    Protein Function

    PRDM14 has several biochemical functions, for example, RNA binding,chromatin DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDM14 itself. We selected most functions PRDM14 had, and list some proteins which have the same functions with PRDM14. You can find most of the proteins on our site.

    Function Related Protein
    protein binding STARD13,C5orf20,CCDC103,PPP3R1,KHDRBS2,RRAS2,DNMT3A,RBM17,CCDC60,SLC3A1
    methyltransferase activity PRDM13,COMTA,METTL23,DNMT3AB,METTL10,DNMT3AA,SETD1BA,PRMT8B,SETD9,PRMT9
    chromatin DNA binding MED1,RELA,HIST1H1E,FOXC2,EZH2,GATA1,SRF,H2AFY,INSM1B,HIST1H1A
    metal ion binding ZNF776,COL27A1A,UNC13B,NEK3,RXRGB,PARN,CCDC76,CYP4A14,AMY1B,PVALB2
    RNA binding SNRPF,LOC81691,RBMY1B,DDX53,U2AF1L4,MRPL12,DUSP11,NOVA1,RAVER1,HNRNPF

    Interacting Protein

    PRDM14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDM14 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDM14.

    ATPAF2;HEXIM2;CBFA2T2;Hoxa1;EIF4E2;RAD51D

    Resources

    Research Area

    Primordial Germ Cell Markers
    Cancer Stem Cell Transcription Factors
    Pluripotent Stem Cell Transcription Factors

    References

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