PPHLN1
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Official Full Name
periphilin 1 -
Overview
The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. -
Synonyms
PPHLN1;periphilin 1;periphilin-1;Gastric cancer antigen Ga50;PPHLN_HUMAN;OTTHUMP00000241107;OTTHUMP00000241108;OTTHUMP00000241109;OTTHUMP00000241110;OTTHUMP00000241113;OTTHUMP00000241114;OTTHUMP00000241115;OTTHUMP00000241116;OTTHUMP00000241117;OTTHUMP00000241118;HSPC206;HSPC232
Recombinant Proteins
- Chicken
- Human
- Zebrafish
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- His&T7
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPHLN1-2438C | Recombinant Chicken PPHLN1 | Mammalian Cell | Chicken | His |
|
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| PPHLN1-28673TH | Recombinant Human PPHLN1, His-tagged | E.coli | Human | His | 68-293 a.a. |
|
| PPHLN1-5012Z | Recombinant Zebrafish PPHLN1 | Mammalian Cell | Zebrafish | His |
|
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| Pphln1-8036M | Recombinant Mouse Pphln1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Met1~Phe381 |
|
| PPHLN1-2976HCL | Recombinant Human PPHLN1 293 Cell Lysate | HEK293 | Human | Non |
|
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| Pphln1-5037M | Recombinant Mouse Pphln1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
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| PPHLN1-961H | Recombinant Human PPHLN1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
PPHLN1 involved in several pathways and played different roles in them. We selected most pathways PPHLN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPHLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PPHLN1 has several biochemical functions, for example, poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPHLN1 itself. We selected most functions PPHLN1 had, and list some proteins which have the same functions with PPHLN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BCL2L13,C9orf100,HPSE,WSB1,ITGA6,TYR,SRRT,TBX15,LPP,CCDC101 |
| poly(A) RNA binding | HSPD1,FASTKD1,CIRH1A,CPEB2,CPEB4,IGF2BP1,ZNF207,PDCD11,PURG,UTP14A |
Interacting Protein
PPHLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPHLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPHLN1.
CCDC57;MTUS2;TSGA10;SNCAIP;CDK6;VIM;BCL2L1;SQSTM1;TP53BP2;TOMM20;CDC37;rpoD;SEPT8
Resources
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References
- Ludin, P; Nilsson, D; et al. Genome-Wide Identification of Molecular Mimicry Candidates in Parasites. PLOS ONE 6:-(2011).
- Soehn, AS; Franck, T; et al. Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease. NEUROGENETICS 11:203-215(2010).
