POU2F3
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Official Full Name
POU class 2 homeobox 3 -
Overview
This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
POU2F3;POU class 2 homeobox 3;POU domain class 2, transcription factor 3;POU domain, class 2, transcription factor 3;Epoc 1;OCT11;PLA 1;Skn 1a;Epoc1;HGNC19864;Oct 11;Octamer binding transcription factor 11;PLA1 protein;POU domain;POU transcription factor;Transcription factor Skn1;OTTHUMP00000231987;OTTHUMP00000231988;octamer-binding protein 11;transcription factor PLA-1;transcription factor Skn-1;POU domain transcription factor OCT11a;octamer-binding transcription factor 11;PLA1;PLA-1;Epoc-1;OCT-11;OTF-11;Skn-1a
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POU2F3-4258Z | Recombinant Zebrafish POU2F3 | Mammalian Cell | Zebrafish | His |
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| POU2F3-7864Z | Recombinant Zebrafish POU2F3 | Mammalian Cell | Zebrafish | His |
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| POU2F3-3002HCL | Recombinant Human POU2F3 293 Cell Lysate | HEK293 | Human | Non |
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| POU2F3-1738H | Recombinant Human POU2F3 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| POU2F3-1738H-B | Recombinant Human POU2F3 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Pou2f3-5019M | Recombinant Mouse Pou2f3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| POU2F3-6682H | Recombinant Human POU2F3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| POU2F3-981HFL | Recombinant Full Length Human POU2F3 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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Involved Pathway
POU2F3 involved in several pathways and played different roles in them. We selected most pathways POU2F3 participated on our site, such as Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with POU2F3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | C3A.1,IFNPHI3,ARNTL,BF2,POLR2A,MED8,TAF9B,HLA-DQB1,OAS1,IRF7 |
Protein Function
POU2F3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POU2F3 itself. We selected most functions POU2F3 had, and list some proteins which have the same functions with POU2F3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein dimerization activity | FAP,MNT,MITFB,TCF21,MITFA,TFAP2B,HPS4,PIP,LDB1A,NCOA2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | FOSL2,TFE3A,NR5A2,SREBF1,MESP1,MSX2,ZNF331,TCF4,NEUROD6,RELA |
| protein binding | UPP2,PPIAL4A,NAP1L2,RNF168,HIST1H4F,SYN1,LSM2,TCF4,TNNT1,CETN1 |
| sequence-specific DNA binding | NEUROG2,EMX1,HIVEP2,HOXB2A,ZNF215,NKX2.9,FOXC1B,MEOX2,SOX14,POU3F1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | GLIS2,POU4F1,SIX2,NOBOX,SMAD4,ARNT2,BSX,SREBF1,SP1,KLF15 |
Interacting Protein
POU2F3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POU2F3 here. Most of them are supplied by our site. Hope this information will be useful for your research of POU2F3.
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