PON2
-
Official Full Name
paraoxonase 2 -
Overview
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] -
Synonyms
PON2;paraoxonase 2;serum paraoxonase/arylesterase 2;PON 2;A-esterase 2;arylesterase 2;paraoxonase nirs;aromatic esterase 2;serum aryldialkylphosphatase 2
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Rat
- Mouse
- Cynomolgus
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- His
- His&T7
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PON2 involved in several pathways and played different roles in them. We selected most pathways PON2 participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PON2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | NAT,HPDA,PLB1,POLE,NT5M,ACLY,FASN,LPCAT2,BCO1L,GPI |
Protein Function
PON2 has several biochemical functions, for example, arylesterase activity,identical protein binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PON2 itself. We selected most functions PON2 had, and list some proteins which have the same functions with PON2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arylesterase activity | CA1,PON3,Car2,CA2,C20orf3,CAR1,PON1,APMAP |
| metal ion binding | ZFP110,ZFP521,IMPDH1A,GM5136,RPS27.1,PPM1E,Scd1,MOXD1L,GGTA1,COL1A1 |
| identical protein binding | VPS41,ATXN10,SH3GL3,TLE1,THG1L,SLK,SMG9,COL1A2,COL18A1,RIPK1 |
Interacting Protein
PON2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PON2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PON2.
env;env;GRB2;ERBB3
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