POMC
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Official Full Name
proopiomelanocortin -
Overview
Melanocyte-stimulating hormone belongs to a group called the melanocortins. This group includes ACTH, alpha-MSH, beta-MSH and gamma-MSH; these peptides are all cleavage products of a large precursor peptide called pro-opiomelanocortin (POMC). Alpha-MSH is the most important melanocortin for pigmentation. It increases the pigmentation of skin by increasing melanin production in melanocytes. -
Synonyms
POMC;proopiomelanocortin;LPH;MSH;NPP;POC;ACTH;CLIP;adrenocorticotropic hormone;adrenocorticotropin;alpha-melanocyte stimulating hormone;beta-endorphin;beta-lipotropin;beta-melanocyte stimulating hormone;Pro-opiomelanocortin;Corticotropin-lipotropin;Melanotropin gamma;Gamma-MSH;Potential peptide;Corticotropin;Adrenocorticotropic hormone;Melanotropin alpha;Alpha-MSH;Corticotropin-like intermediary peptide;Lipotropin beta;Beta-LPH;Lipotropin gamma;Gamma-LPH;Melanotropin beta;Beta-MSH;Beta-endorphin;Met-enkephalin;pro-opiomelanocortin;beta-LPH;beta-MSH;alpha-MSH;gamma-LPH;gamma-MSH;beta-endorphin;met-enkephalin;lipotropin beta;lipotropin gamma;melanotropin beta;OTTHUMP00000119991;OTTHUMP00000200964;OTTHUMP00000200965;OTTHUMP00000200966;melanotropin alpha;melanotropin gamma;pro-ACTH-endorphin;adrenocorticotropin;corticotropin-lipotropin;proopiomelanocortin preproprotein;corticotropin-like intermediary peptide
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Synthetic
- Human
- HEK293
- His
- Non
- His&GST
- His&Fc&Avi
Involved Pathway
POMC involved in several pathways and played different roles in them. We selected most pathways POMC participated on our site, such as Melanogenesis,Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with POMC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipocytokine signaling pathway | PPARA,PRKAG2A,ACSL1,PPARGC1A,PCK2,MAPK10,IRS1,NFKB1,PPARAB,ACSL5 |
| Melanogenesis | KITB,PLCB4,CREB1A,MAPK1,GSK3B,Fzd4,RAF1A,CAMK2A,FZD9B,KIT |
Protein Function
POMC has several biochemical functions, for example, G-protein coupled receptor binding,hormone activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POMC itself. We selected most functions POMC had, and list some proteins which have the same functions with POMC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| type 4 melanocortin receptor binding | MRAP2,MRAP,a,ASIP |
| receptor binding | FGF11A,CD58,C3,STOML2,CHRNA10,LTB,PDGFRB,POU2F1,RSPO2,FGF24 |
| hormone activity | PTH,SCT,EDN2,SMTLA,GUCA2A,PRL2C2,GCG,INHBAB,ADM,IAPP |
| G-protein coupled receptor binding | GNAT3,FYN,HSPA1A,PARK2,AKAP5,CORT,UCN3L,PSAPL1,DNAJA1,RSPO2 |
| type 3 melanocortin receptor binding | MRAP2,MRAP,ASIP,a |
| type 1 melanocortin receptor binding | AGRP2,MRAP2,MRAP |
Interacting Protein
POMC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POMC here. Most of them are supplied by our site. Hope this information will be useful for your research of POMC.
Resources
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References
- Dieudonne, M; Ramesh, KV; et al. Modeling the interactions between MC2R and ACTH models from human. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 33:770-788(2015).
- Bassi, M; Nakamura, NB; et al. Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function. ACTA PHYSIOLOGICA 213:893-901(2015).
