POLR3A
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Official Full Name
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa -
Overview
The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. -
Synonyms
POLR3A;polymerase (RNA) III (DNA directed) polypeptide A, 155kDa;DNA-directed RNA polymerase III subunit RPC1;hRPC155;RPC1;RPC155;RNA polymerase III subunit C1;RNA polymerase III subunit C160;RNA polymerase III 155 kDa subunit;RNA polymerase III
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLR3A-1639C | Recombinant Chicken POLR3A | Mammalian Cell | Chicken | His |
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| POLR3A-8286Z | Recombinant Zebrafish POLR3A | Mammalian Cell | Zebrafish | His |
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| POLR3A-5353H | Recombinant Human POLR3A protein, His-tagged | E.coli | Human | His | 392-632aa |
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| POLR3A-730H | Recombinant Human POLR3A Protein (392-632 aa), His-SUMO-tagged | E.coli | Human | His&SUMO | 392-632 aa |
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Involved Pathway
POLR3A involved in several pathways and played different roles in them. We selected most pathways POLR3A participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | AK7,PDE1B,POLR2A,RRM1,CANT1,ENTPD2,NT5C2,PAPSS2A,PDE4C,PFAS |
| Metabolic pathways | PRDX6,CYP3A7,NT5C2B,COX15,CCBL1,PLD2,COX6C,AMPD3,NNT,B3GAT3 |
| Pyrimidine metabolism | CTPS2,NT5C2,PNP,NME2B.1,POLE2,NT5C1AA,POLR2K,CANT1,NT5C1A,ENTPD5 |
| RNA polymerase | POLR1C,POLR2E,POLR3D,POLR2B,POLR3GL,POLR1D,POLR2H,POLR2F,POLR2D,POLR1B |
| Cytosolic DNA-sensing pathway | POLR3C,MAVS,ZBP1,IFNA5,IFNB1,IL6,RIPK1L,IL33,POLR3F,POLR3G |
Protein Function
POLR3A has several biochemical functions, for example, DNA binding,DNA-directed RNA polymerase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR3A itself. We selected most functions POLR3A had, and list some proteins which have the same functions with POLR3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF12,HIST2H2BE,HIST1H2AG,ZFP488,CXXC1A,EVE1,NR5A2,NACA,ZNF71,MYCS |
| DNA-directed RNA polymerase activity | POLR2M,POLR2GL,CD3EAP,POLR2B,POLR2I,POLR3B,POLR2J,POLR2EB,POLRMT,POLR3F |
| metal ion binding | RXRBA,FOXP1,RNF44,PON3,TNFRSF11A,MYLIPA,NME6,HMOX1A,ZNF554,TRIM43B |
Interacting Protein
POLR3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR3A here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR3A.
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