POLR2L

  • Official Full Name

    polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa

  • Overview

    This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.

  • Synonyms

    POLR2L;polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa;polymerase (RNA) II (DNA directed) polypeptide L (7.6kD);DNA-directed RNA polymerases I, II, and III subunit RPABC5;hRPB7.6;hsRPB10b;RBP10;RPABC5;RPB7.6;RPB10beta;DNA directed RNA polymerase II polypeptide L;RNA polymerase II polypeptide L;RPB10;RPB10 homolog;RNA polymerase II 7.6 kDa subunit;DNA-directed RNA polymerase III subunit L;RNA polymerases I, II, and III subunit ABC5

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • Chicken
  • Zebrafish
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
POLR2L-1849H Recombinant Human POLR2L, GST-tagged E.coli Human GST 1-67aa
POLR2L-13102M Recombinant Mouse POLR2L Protein Mammalian Cells Mouse His
POLR2L-3056H Recombinant Human POLR2L, His-tagged E.coli Human His 1-67 a.a.
POLR2L-30688TH Recombinant Human POLR2L E.coli Human Non Full L.
POLR2L-3519R Recombinant Rhesus monkey POLR2L Protein, His-tagged Mammalian Cells Rhesus macaque His
POLR2L-5644C Recombinant Chicken POLR2L Mammalian Cells Chicken His
POLR2L-7432Z Recombinant Zebrafish POLR2L Mammalian Cells Zebrafish His
POLR2L-3027HCL Recombinant Human POLR2L 293 Cell Lysate HEK293 Human Non
POLR2L-3337R Recombinant Rhesus Macaque POLR2L Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
POLR2L-3337R-B Recombinant Rhesus Macaque POLR2L Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Polr2l-5002M Recombinant Mouse Polr2l Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
POLR2L-6927M Recombinant Mouse POLR2L Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
POLR2L-6927M-B Recombinant Mouse POLR2L Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    POLR2L involved in several pathways and played different roles in them. We selected most pathways POLR2L participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epstein-Barr virus infection MAPK10,TP53,GSK3B,H2-Q10,SKP2,GTF2B,HSPA1L,AKT1,TYK2,TRAF2
    Purine metabolism POLR3D,DCK,PNP6,POLR3GLB,NPR2,PDE8B,PRPS1,ADSSL,PKM,AMPD1
    Cytosolic DNA-sensing pathway POLR2H,IFNB1,IFNA21,RIPK1L,AIM2,IFNA5,IFNA16,CCL4L1,NFKBIB,IFNB
    Metabolic pathways SAT1A.2,CNDP1,CRLS1,ANPEP,ATP5J,PYGM,NT5C1B,SLC27A5,Akr1b3,ACSM2
    Pyrimidine metabolism TYMS,PRIM2,POLR2E,POLR1A,ENTPD6,NME1,NT5C3L,NME3,AK9,NME5
    Huntingtons disease DNAH6,UQCRH,HAP1,HTT,NRF1,PLCB4,ATP5G3,BDNF,NDUFA12,POLR2C
    RNA polymerase POLR2D,POLR2GL,POLR3GL,POLR2K,POLR2B,POLR3D,POLR2G,POLR1E,ZNRD1,POLR3A

    Protein Function

    POLR2L has several biochemical functions, for example, DNA binding,DNA-directed RNA polymerase activity,contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2L itself. We selected most functions POLR2L had, and list some proteins which have the same functions with POLR2L. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to RNA polymerase I activity ZNRD1,POLR2K,POLR2E,POLR1E,POLR1A,POLR2EB,POLR2F,POLR1D,POLR2H,TWISTNB
    DNA binding LHX8,GLI4,ZNF146,ZNF410,ZFP37,MXD4,SIX4B,ZNF471,ESRRGB,HMGB1A
    DNA-directed RNA polymerase activity POLR2J,PRIM2,POLR2B,POLR3C,POLR3K,POLR3B,CCDC111,CRCP,MED21,POLRMT
    zinc ion binding SEC23B,RNF180,CA4B,CPN1,GCM1,BRF2,RBM20,NAPEPLD,ADAMTSL3,XIAP
    contributes_to RNA polymerase III activity POLR2F,POLR3C,POLR3K,POLR3E,POLR2K,POLR1C,POLR3GL,POLR3G,POLR3H,CRCP
    protein binding NLRP12,HDAC7,MYOC,TCTEX1D1,GLB1,STK10,F5,CRELD2,RNF170,PNMA2
    contributes_to RNA polymerase II activity POLR2E,POLR2J2,POLR2EB,POLR2K,POLR2J,POLR2H,POLR2C,POLR2B,POLR2F,POLR2A

    Interacting Protein

    POLR2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2L here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2L.

    ZBTB14;COIL;REL;TP53BP2;PHC2;BANP;L3MBTL3

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