POLG
-
Official Full Name
polymerase (DNA directed), gamma -
Overview
exhibits DNA polymerase activity; may mediate the final step of mitochondrial DNA repair -
Synonyms
POLG;polymerase (DNA directed), gamma;DNA polymerase subunit gamma-1;POLG1;POLGA;PolG-alpha;PolG, catalytic subunit;mitochondrial DNA polymerase catalytic subunit;PEO;MDP1;SCAE;MIRAS;SANDO;MTDPS4A;MTDPS4B;FLJ27114
Recombinant Proteins
- Human
- Rat
- Hepatitis C virus genotype 1b
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| POLG-1832H | Recombinant Human POLG, GST-tagged | E.coli | Human | GST | 888-1239aa | |
| POLG-317H | Recombinant Human POLG Protein, His-tagged | E.coli | Human | His | Trp1041~Pro1239 | |
| POLG-1525H | Recombinant Human POLG protein | E.coli | Human | Non | Full L. |
|
| POLG-28364TH | Recombinant Human POLG | Wheat Germ | Human | Non | 110 amino acids |
|
| POLG-4565R | Recombinant Rat POLG Protein | Mammalian Cell | Rat | His |
|
|
| POLG-632H | Recombinant Human POLG protein | Human | Non |
|
||
| POLG-1528H | Recombinant Hepatitis C virus genotype 1b POLG Protein (S2420-R2989) | E.coli | Hepatitis C virus genotype 1b | Non | S2420-R2989 |
|
| POLG-1529H | Recombinant Hepatitis C virus genotype 1b POLG Protein (S2420-R2989), His-tagged | E.coli | Hepatitis C virus genotype 1b | His | S2420-R2989 |
|
| POLG-4225R | Recombinant Rat POLG Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| POLG-4225R-B | Recombinant Rat POLG Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
Involved Pathway
POLG involved in several pathways and played different roles in them. We selected most pathways POLG participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GMDS,NDUFB10,SARDH,PISD,PCYT2,UXS1,B3GNTL2,PIGK,PNLIP,ATP5E |
Protein Function
POLG has several biochemical functions, for example, 3-5 exonuclease activity,DNA binding,DNA-directed DNA polymerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLG itself. We selected most functions POLG had, and list some proteins which have the same functions with POLG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-directed DNA polymerase activity | POLE4,POLH,POLI,POLE,POLA2,POLD2,PRIMPOL,POLM,DNTT,CHRAC1 |
| DNA binding | RAG1,TGIF2LX,RXRA,ZHX2,ARNTL1A,HJURP,ABL1,HIST1H2AF,C3orf37,PHTF2 |
| protease binding | SERPINB3,SERPINF2,ITGA3,MBL1,FURIN,SERPINB6,CRADD,TIMP2,ITGB1,LRP1 |
| 3-5 exonuclease activity | EXOSC10,ERI1,RAD9A,RAD1,TREX1,EXD1,REXO2,APEX1,EXD2,RAD9 |
| chromatin binding | HDAC7A,WDR82,NR5A1A,GATA2,TLE1,DMRT1,HINFP,NUPR1,SIRT2,POU5F3 |
| protein binding | ARHGEF38,ACAT2,MTF1,DSCAM,SCRN2,PDCD2,MS4A3,ID1,TLE4,TOMM70A |
Interacting Protein
POLG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLG here. Most of them are supplied by our site. Hope this information will be useful for your research of POLG.
POLG2;Dlg4;q2i360_hbv;ssdna_dn
Resources
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References
- Arkadir, D; Meiner, V; et al. Teaching NeuroImages: Hypertrophic olivary degeneration in a young man with POLG gene mutation. NEUROLOGY 84:e59-e59(2015).
- Golob, MJ; Tian, L; et al. Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function. JOURNAL OF BIOMECHANICS 48:405-412(2015).
