POLD2
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Official Full Name
polymerase (DNA directed), delta 2, regulatory subunit 50kDa -
Overview
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase;and 3 to 5 exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is;required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear;antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript;variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the;long arm of chromosome 5. -
Synonyms
POLD2;polymerase (DNA directed), delta 2, regulatory subunit 50kDa;polymerase (DNA directed), delta 2, regulatory subunit (50kD);DNA polymerase delta subunit 2;DNA polymerase delta subunit p50;DNA polymerase subunit delta 2;DNA polymerase subunit delta p50;DPOD2_HUMAN;POLD 2;OTTHUMP00000159252;OTTHUMP00000209249;OTTHUMP00000209250
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
POLD2 involved in several pathways and played different roles in them. We selected most pathways POLD2 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyrimidine metabolism | POLE,CMPK1,POLR2L,TXNRD3,NT5C1AA,PNP,CMPK2,NME2B.1,PNP6,NME5 |
| Base excision repair | PCNA,XRCC1,PARP2,NEIL2,PARP1,APEX1,POLE,MUTYH,NEIL1,HMGB1A |
| Homologous recombination | EME1,BRCA2,POLD4,POLD1,TOP3A,TOP3B,RPA3,MUS81,RAD51C,NBN |
| Purine metabolism | CANT1,PDE4A,PDE11A,PDE1A,PPAT,AK9,NME2B.1,RRM1,POLR3B,PDE5A |
| DNA Replication | GMNN,RNASEH2C,RFC3,rnhA,POLE4,PRIM1,MCM6L,PRIM2,MCM2,POLD1 |
| Mismatch repair | POLD1,MLH1,RFC4,RFC2,RPA2,RPA4,MSH6,RFC1,RFC5,RPA3 |
| Metabolic pathways | ADH2-1,MGAT4A,CYP24A1,ALAS1,CDO1,MTMR7B,Aldh1a7,GPAT2,OXSR1,SCP2 |
| HTLV-I infection | NRP1,SFPI1,FZD6,NFATC2,TLN1,PDGFB,HLA-C,CD40,NFKB1,HLA-DQA1 |
| Nucleotide Excision Repair | ERCC3,RAD23AA,RAD23B,RFC2,POLE3,GTF2H3-2,GTF2H2C,LIG1,RFC3,MCRS1 |
Protein Function
POLD2 has several biochemical functions, for example, DNA binding,DNA-directed DNA polymerase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLD2 itself. We selected most functions POLD2 had, and list some proteins which have the same functions with POLD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LITAF,KIAA1609,SERBP1,MDH1,SH3BP4,SUMO3,CC2D1B,GMNN,CASQ2,HSPA1L |
| DNA-directed DNA polymerase activity | POLE3,POLG2,MYBBP1A,POLD4,POLI,POLK,POLD3,PAPD7,POLN,POLM |
| DNA binding | SIX3A,ZNF311,ZFR,KLF9,ZNF593,FOXO3,ZNF697,SLC2A4RG,MIER1A,HOXC3A |
Interacting Protein
POLD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLD2.
POLD1;POLD3;PCNA;POLD4
Resources
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References
- Lee, MO; Yang, E; et al. Mapping and genotypic analysis of the NK-lysin gene in chicken. GENETICS SELECTION EVOLUTION 46:-(2014).
- Lee, YS; Gregory, MT; et al. Human Pol zeta purified with accessory subunits is active in translesion DNA synthesis and complements Pol. in cisplatin bypass. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:2954-2959(2014).
