POLD1

  • Product List
  • Overview
  • Review / Q&A

  • Official Full Name

    polymerase (DNA directed), delta 1, catalytic subunit 125kDa

  • Overview

    This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase;and 3 to 5 exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced;transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of;chromosome 6.

  • Synonyms

    POLD1;polymerase (DNA directed), delta 1, catalytic subunit 125kDa;POLD, polymerase (DNA directed), delta 1, catalytic subunit (125kD);DNA polymerase delta catalytic subunit;CDC2;CDC2 homolog (S. cerevisiae);CDC2 homolog;DNA polymerase subunit del

Recombinant Proteins

  • Mouse
  • Human
  • Zebrafish
  • Rat
  • Mammalian Cells
  • E.coli
  • HEK293
  • Wheat Germ
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
POLD1-13068M Recombinant Mouse POLD1 Protein Mammalian Cells Mouse His
POLD1-28360TH Recombinant Human POLD1, His-tagged E.coli Human His 929-1102 a.a.
POLD1-3654Z Recombinant Zebrafish POLD1 Mammalian Cells Zebrafish His
POLD1-4562R Recombinant Rat POLD1 Protein Mammalian Cells Rat His
POLD1-8025H Recombinant Human POLD1 protein, His & GST-tagged E.coli Human GST&His Met41~Phe254
POLD1-3053HCL Recombinant Human POLD1 293 Cell Lysate HEK293 Human Non
POLD1-04H Recombinant Human POLD1 Protein, His tagged E.coli Human His Arg850-end
Pold1-1958M Recombinant Mouse Pold1 Protein, His-tagged E.coli Mouse His Ser29-Gly260
POLD1-20HFL Recombinant Full Length Human POLD1 Protein, GST tagged Wheat Germ Human GST Full L. 1-1107aa
POLD1-4222R Recombinant Rat POLD1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
POLD1-4222R-B Recombinant Rat POLD1 Protein Pre-coupled Magnetic Beads HEK293 Rat
POLD1-4951H Recombinant Human POLD1 Protein (Met41-Phe254), N-GST tagged E.coli Human GST Met41-Phe254
POLD1-6904M Recombinant Mouse POLD1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
POLD1-6904M-B Recombinant Mouse POLD1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

Involved Pathway

POLD1 involved in several pathways and played different roles in them. We selected most pathways POLD1 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pyrimidine metabolism TYMP,NME2A,UPP2,CDA,POLR2D,POLE,POLR1A,TXNRD3,POLR2B,ENTPD8
Mismatch repair PMS2,SSBP1,RFC5,MSH3,RPA3,RPA1,RPA4,RFC2,POLD4,RPA2
Nucleotide Excision Repair POLD2,GTF2H3,RPA1,RFC5,INO80E,COPS4,COPS3,GPS1,RPA4,POLE3
DNA Replication PCNA,POLE4,GMNN,MCM5,DBF4,PRIM1,RFC2,RNASEH2B,RPA3,SSBP1
Metabolic pathways ATP6V0CA,PDHA1B,CCBL2,LDHBA,DCXR,CKMA,ALAS1,UPP1,PIGP,B3GAT3
HTLV-I infection VDAC3,PDGFB,CCND1,IKBKB,SLC2A1,TERT,HLA-DMA,WNT11,FZD6,WNT5A
Base excision repair POLD4,PARP1,OGG1,MUTYH,LIG1,POLE,SMUG1,APEX2,APEX1,PARP4
Purine metabolism POLD2,POLR3D,PDE4A,ITPA,RRM2B,HDDC3,PPAT,NPR2,PDE6A,ADPRM
Homologous recombination EME1,RAD54B,FUZ,TOP3A,RAD51C,MRE11A,NBN,RPA4,RAD51L3,RAD51B

Protein Function

POLD1 has several biochemical functions, for example, 3-5-exodeoxyribonuclease activity,4 iron, 4 sulfur cluster binding,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLD1 itself. We selected most functions POLD1 had, and list some proteins which have the same functions with POLD1. You can find most of the proteins on our site.

Function Related Protein
nucleotide binding HIPK3B,HNRPDL,GRK7A,RBFOX2,UBE2IA,NME2B.2,POLR2D,U2AF2B,RBM39B,DOM3Z
metal ion binding PDE1B,COL10A1,CYGB1,GALNT6,ZDHHC15A,C2,Car14,LFNG,HDDC3,CDK5RAP1
DNA binding PAX1,KDM5C,APP,HDGF,ESRRGA,PRDM2,TCEB3B,RUNX1,DNASE2,H1FX
chromatin binding SMC3,BCL6,ASF1A,EWSR1A,NKAP,ENY2,HINFP,TCF7,TFAP2A,CDK9
DNA-directed DNA polymerase activity CCDC111,PRIMPOL,POLI,POLK,POLD2,POLN,POLE3,POLB,POLA2,POLG
4 iron, 4 sulfur cluster binding ISCA2,CDKAL1,ISCA1,RSAD1,NDUFS8A,RSAD2,DNA2,NDUFS8,DPYD,NDUFS2
3-5-exodeoxyribonuclease activity TREX2,TREX1
protein binding RPS27L,NOC2L,SMNDC1,FLT1,USP9X,ZCCHC12,AUP1,SIM1,APTX,NRL
damaged DNA binding RAD23AB,TP53,RPA2,XPC,RUVBL2,XRCC6,TRP53,PCNA,FANCG,APEX1

Interacting Protein

POLD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLD1.

POLD4;POLD2

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