PNPLA8
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Official Full Name
patatin-like phospholipase domain containing 8 -
Overview
This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family;are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is;a calcium-independent phospholipase. A pseudogene of this gene is located on the X chromosome. Multiple transcript;variants encoding different isoforms have been found for this gene. -
Synonyms
PNPLA8;patatin-like phospholipase domain containing 8;calcium-independent phospholipase A2-gamma;IPLA2(GAMMA);IPLA2 2;IPLA2G;PNPLA-gamma;iPLA2 gamma;iPLA2-gamma;patatin-like phospholipase domain-containing protein 8;membrane-associated calcium-i
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Oryctolagus cuniculus (Rabbit)
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- His&Fc&Avi
Involved Pathway
PNPLA8 involved in several pathways and played different roles in them. We selected most pathways PNPLA8 participated on our site, such as Acyl chain remodelling of PC,Acyl chain remodelling of PE,Eicosanoid Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPLA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acyl chain remodelling of PC | PLB1,PLA2G16,PLBD1,PLA2G4B |
| Eicosanoid Synthesis | DPEP1,ALOX5AP |
| Acyl chain remodelling of PE | PLA2G4B,PLA2G16,PLBD1 |
| Phospholipid metabolism | ABHD4,PHOSPHO1,CDS1,ABHD3,PEMT,ARF3,SACM1LB,CEPT1A,CPNE1,PTPMT1 |
| Metabolism of lipids and lipoproteins | COL4A3BP,GPAT2,ANKRD1,CERS3B,INSIG1,CPT2,CERS5,THEM5,MTF1,ARSE |
| Metabolism | LYRM4,PTPMT1,CES1,APOA4B.1,ARSK,CPT2,KCNS3,CYP3A5,NUDT10,SLC2A3 |
| Glycerophospholipid biosynthesis | CHKB,SLC44A5B,PEMT,AWAT1,DGAT1B,PLBD1,GPAT2,PITPNB,ABHD4,CEPT1 |
Protein Function
PNPLA8 has several biochemical functions, for example, calcium-independent phospholipase A2 activity,hydrolase activity,lysophospholipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPLA8 itself. We selected most functions PNPLA8 had, and list some proteins which have the same functions with PNPLA8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-independent phospholipase A2 activity | PLA2G7,PLA2G15,PLA2G4C |
| hydrolase activity | RNASEL4,DESI1,FIGNL1,CTSL1B,DNASE2A,CAPN3A,F2RL1.1,USP12A,USB1,CMBL |
| lysophospholipase activity | PLA2G15,PLA2G4AA,Cel,PLA2G4B,PNPLA6,PNPLA7,ASPG,ENPP2,MGLL,PNPLA7A |
Interacting Protein
PNPLA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPLA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPLA8.
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References
- Huang, CF; Dai, CY; et al. Association of diabetes and PNPLA3 genetic variants with disease severity of patients with chronic hepatitis C virus infection. JOURNAL OF HEPATOLOGY 62:512-518(2015).
- Mandorfer, M; Payer, BA; et al. Revisiting liver disease progression in HIV/HCV-coinfected patients: the influence of vitamin D, insulin resistance, immune status, IL28B and PNPLA3. LIVER INTERNATIONAL 35:876-885(2015).
