PNP
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Official Full Name
purine nucleoside phosphorylase -
Overview
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. -
Synonyms
PNP;purine nucleoside phosphorylase;NP, nucleoside phosphorylase;PUNP;FLJ97312;FLJ94043;FLJ97288;Inosine phosphorylase;MGC117396;MGC125915;MGC125916;NP;Np1;Nucleoside phosphorylase;Pnp1;PNPH_HUMAN;PRO1837;Purine nucleoside orthophosphate ribosyltransferase;OTTHUMP00000163992;purine-nucleoside:orthophosphate ribosyltransferase
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Insect cells
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- His&SUMO
- Myc&DDK
- Flag
Involved Pathway
PNP involved in several pathways and played different roles in them. We selected most pathways PNP participated on our site, such as Purine metabolism,Pyrimidine metabolism,Nicotinate and nicotinamide metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | NDUFV1,ACY1,AK9,Ckmm,PGK1,FOLH1,TPO,TUSC3,ENO3,CECR1 |
| Pyrimidine metabolism | CANT1,POLR2L,NT5C,ENTPD5,DCK,POLR2A,TK1,POLR2B,POLR2C,NT5C1AA |
| Purine metabolism | PGM2,POLR2J2,HDDC3,GUCY2C,NT5C3A,CECR1A,POLR3E,POLR1A,PDE5AB,ENTPD6 |
| Nicotinate and nicotinamide metabolism | NT5C3A,NUDT12,NADKB,NT5C3L,NT5C2,NMRK1,NADK,AOX3,ENPP1,AOX1 |
Protein Function
PNP has several biochemical functions, for example, drug binding,nucleoside binding,phosphate ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PNP itself. We selected most functions PNP had, and list some proteins which have the same functions with PNP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleoside binding | CDA,POLA1,ACTN4,AASS |
| purine-nucleoside phosphorylase activity | PNP4B,PNP5B,PNP4A,PNP6,PNP5A |
| purine nucleobase binding | PYGL |
| phosphate ion binding | G6PC,MTHFD2,ADSS,RELA,RPH3A,OTC,CHST14,SH2B3,ADSSL1,SLC34A2 |
| drug binding | CYP2C9,NAMPT,PDE4C,PDXK,IL2RA,FSCN1,CHRNB4,MTOR,FASN,PPARA |
Interacting Protein
PNP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNP here. Most of them are supplied by our site. Hope this information will be useful for your research of PNP.
EPB41;MCC;HLA-B;IKBKE;NOS1AP;TP53;APLP1;RBM48;RIF1;CCDC90B;ZHX1;VCAM1;MNDA;IFI16;Ddb1;Tmed10;Batf3
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References
- Stork, ACJ; Notermans, NC; et al. Fc gamma receptor IIIA genotype is associated with rituximab response in antimyelin-associated glycoprotein neuropathy. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 85:916-918(2014).
- Guillen, KP; Kurkjian, C; et al. Targeted enzyme prodrug therapy for metastatic prostate cancer - a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase. JOURNAL OF BIOMEDICAL SCIENCE 21:-(2014).
