PLOD2
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Official Full Name
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -
Overview
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
PLOD2;procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2;procollagen lysine, 2 oxoglutarate 5 dioxygenase (lysine hydroxylase) 2;procollagen-lysine,2-oxoglutarate 5-dioxygenase 2;LH2;lysyl hydroxlase 2;2-oxoglutarate 5-dioxygenase 2;Lysine hydroxylase 2;Lysyl hydroxylase 2;OTTHUMP00000215204;OTTHUMP00000215205;OTTHUMP00000215206;PLOD 2;PLOD2_HUMAN;Procollagen lysine 2 oxoglutarate 5 dioxygenase 2;Procollagen-lysine;Telopeptide lysyl hydroxylase;TLH
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Insect Cell
- HEK293T
- In Vitro Cell Free System
- GST
- His&T7
- His
- Non
- His&Myc
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PLOD2-1793H | Recombinant Human PLOD2, GST-tagged | E.coli | Human | GST | 459-540aa | |
| PLOD2-1181H | Recombinant Human PLOD2 protein, His & T7-tagged | E.coli | Human | His&T7 | Lys644~Pro737 |
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| PLOD2-1763Z | Recombinant Zebrafish PLOD2 | Mammalian Cell | Zebrafish | His |
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| PLOD2-31030TH | Recombinant Human PLOD2 | Wheat Germ | Human | Non | 732 amino acids |
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| PLOD2-5573Z | Recombinant Zebrafish PLOD2 | Mammalian Cell | Zebrafish | His |
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| PLOD2-3100HCL | Recombinant Human PLOD2 293 Cell Lysate | HEK293 | Human | Non |
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| Plod2-2343M | Recombinant Mouse Plod2 protein, His-Myc-tagged | Insect Cell | Mouse | His&Myc | 26-737aa |
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| PLOD2-35H | Recombinant Human PLOD2 Protein, Myc/DDK-tagged | HEK293T | Human | Myc&DDK |
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| PLOD2-377HF | Recombinant Full Length Human PLOD2 Protein | In Vitro Cell Free System | Human | Full L. 732 amino acids |
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| Plod2-4907M | Recombinant Mouse Plod2 protein, His-Myc-tagged | E.coli | Mouse | His&Myc | 26-737aa |
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| Plod2-4939M | Recombinant Mouse Plod2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| PLOD2-657H | Recombinant Human PLOD2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
PLOD2 involved in several pathways and played different roles in them. We selected most pathways PLOD2 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLOD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysine degradation | AGPHD1,GCDHB,NSD1,ASH1L,HADH,EHMT2,SUV39H1,PLOD1,SUV39H2,OGDH |
Protein Function
PLOD2 has several biochemical functions, for example, L-ascorbic acid binding,iron ion binding,procollagen-lysine 5-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLOD2 itself. We selected most functions PLOD2 had, and list some proteins which have the same functions with PLOD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| procollagen-lysine 5-dioxygenase activity | PLOD3,FAM125B,PLOD1A,PLOD1 |
| iron ion binding | CYP4V2,CYP51A1,CYP2C9,CYP2D26,CYP4F14,HIF1AN,CH25HL2,CYP2P6,TH2,HBE |
| L-ascorbic acid binding | EGLN1B,P3H2,OGFOD2,LEPREL2,PAM,TMLHE,P4HA1B,P4HA3,OGFOD3,PLOD1A |
Interacting Protein
PLOD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLOD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLOD2.
Fam107b;RUVBL2;MYC;cona_canen;Anxa2;HNRNPH2;q76353_9hiv1;ATG5;ITGB1BP2
Resources
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References
- Valverde-Franco, G; Hum, D; et al. The in Vivo Effect of Prophylactic Subchondral Bone Protection of Osteoarthritic Synovial Membrane in Bone-Specific Ephb4-Overexpressing Mice. AMERICAN JOURNAL OF PATHOLOGY 185:335-346(2015).
- Monthoux, C; de Brot, S; et al. Skin malformations in a neonatal foal tested homozygous positive for Warmblood Fragile Foal Syndrome. BMC VETERINARY RESEARCH 11:-(2015).
