PLCH1
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Official Full Name
phospholipase C, eta 1 -
Overview
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes;that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol;1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 (PubMed 15702972)). -
Synonyms
PLCH1;phospholipase C, eta 1;phospholipase C like 3 , PLCL3;1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1;DKFZp434C1372;KIAA1069;MGC117152;PLCeta1;PLC-L3;PLC eta 1;PLC-eta-1;phospholipase C-eta-1;phospholipase C-eta1a;phosph
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PLCH1-1766H | Recombinant Human PLCH1, GST-tagged | E.coli | Human | GST | 1273-1655aa | |
| PLCH1-1023H | Recombinant Human PLCH1 protein, His & T7-tagged | E.coli | Human | His&T7 | Met1~Ala237 |
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| PLCH1-12926M | Recombinant Mouse PLCH1 Protein | Mammalian Cell | Mouse | His |
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| PLCH1-6819M | Recombinant Mouse PLCH1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PLCH1-6819M-B | Recombinant Mouse PLCH1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PLCH1 involved in several pathways and played different roles in them. We selected most pathways PLCH1 participated on our site, such as Inositol phosphate metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | INPPL1A,PIP5K1A,IPMK,MTMR2,MTMR8,PTEN,CDIPT,TPI1,SYNJ2,MTMR7B |
| Metabolic pathways | AK5,MIBP2,TPH1A,HSD3B4,ATP6V1E1,FUT9A,EXTL3,MGAT4B,ALG8,ALDH3B2 |
Protein Function
PLCH1 has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipase C activity,phosphatidylinositol phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCH1 itself. We selected most functions PLCH1 had, and list some proteins which have the same functions with PLCH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol phospholipase C activity | PLCD4,CASR,PLCD3A,BDKRB2,PLCB2,PLCH2,PLCE1,PLCL1,PLCD3,PLCB4 |
| calcium ion binding | MYL5,PCDHB13,EPDL1,ACTN2,PLA2G4B,PCDH1A6,EFEMP2B,BMP1,PCDHGA6,PCDH2AB3 |
| signal transducer activity | PDCD1,GPR25,TAAR7A,HTR2CL1,CNOT7,TAS2R130,TAS2R129,OLFR470,TMTOPS2B,PLCZ1 |
Interacting Protein
PLCH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCH1.
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References
- Saleh, SN; Albert, AP; et al. Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes. JOURNAL OF PHYSIOLOGY-LONDON 587:5361-5375(2009).
- Peppiatt-Wildman, CM; Albert, AP; et al. Endothelin-1 activates a Ca2+-permeable cation channel with TRPC3 and TRPC7 properties in rabbit coronary artery myocytes. JOURNAL OF PHYSIOLOGY-LONDON 580:755-764(2007).
