PLA2G4A

  • Official Full Name

    phospholipase A2, group IVA (cytosolic, calcium-dependent)

  • Overview

    This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

  • Synonyms

    PLA2G4A;phospholipase A2, group IVA (cytosolic, calcium-dependent);PLA2G4;cytosolic phospholipase A2;cPLA2 alpha;cPLA2;lysophospholipase;phospholipase A2 group IVA;phosphatidylcholine 2-acylhydrolase;calcium-dependent phospholipid-binding protein;cPLA2-alpha;MGC126350

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • E.coli
  • Insect Cell
  • Sf21 Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • Mamanlian cells
  • HEK293T
  • GST
  • His&Flag
  • His
  • Non
  • Myc&DDK
  • Flag
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PLA2G4A-1752H Recombinant Human PLA2G4A, GST-tagged E.coli Human GST 1-350aa
PLA2G4A-42H Active Recombinant Human PLA2G4A protein, FLAG/His-tagged Insect Cell Human His&Flag 1-749 a.a.
PLA2G4A-752H Active Recombinant Human PLA2G4A Protein, His-tagged Sf21 Insect Cell Human His Met1-Ala749
PLA2G4A-12894M Recombinant Mouse PLA2G4A Protein Mammalian Cell Mouse His
PLA2G4A-30736TH Recombinant Human PLA2G4A Wheat Germ Human Non 110 amino acids
PLA2G4A-526H Recombinant Human PLA2G4A protein, MYC/DDK-tagged HEK293 Human Myc&DDK
PLA2G4A-557H Recombinant Human PLA2G4A, His-tagged E.coli Human His
PLA2G4A-6974C Recombinant Chicken PLA2G4A Mammalian Cell Chicken His
PLA2G4A-3141HCL Recombinant Human PLA2G4A 293 Cell Lysate HEK293 Human Non
PLA2G4A-12895M Recombinant Mouse PLA2G4A Protein, His-tagged E.coli Mouse His 1-178 a.a.
PLA2G4A-4321HFL Recombinant Full Length Human PLA2G4A protein, Flag-tagged Mamanlian cells Human Flag Full L.
Pla2g4a-4901M Recombinant Mouse Pla2g4a Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
PLA2G4A-4924H Recombinant Human PLA2G4A Protein (Met1-Ser178), N-His tagged E.coli Human His Met1-Ser178
PLA2G4A-6078H Recombinant Human PLA2G4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
PLA2G4A-6799M Recombinant Mouse PLA2G4A Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PLA2G4A-6799M-B Recombinant Mouse PLA2G4A Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PLA2G4A involved in several pathways and played different roles in them. We selected most pathways PLA2G4A participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway GNG2,PLA2G12B,RAPGEF5,CALM2,PLA2G2D,MRAS,VEGFC,FGF9,GNG8,MAPK10
    Inflammatory mediator regulation of TRP channels TRPA1,PPP1CC,PLA2G6,PIK3CD,F2RL1,GNAS,MAPK10,CYP4A14,CALM2,PLCB3
    Metabolic pathways NDUFA7,PIP5K1AA,PSPH,CYP4A10,UPRT,MAOB,CERS5,AOX3L1,HPDB,ASPA
    VEGF signaling pathway RAF1B,VEGFAB,MAPKAPK2,SPHK2,AKT2L,PTGS2B,MAPK3,PRKCBB,PPP3CCA,PTGS2
    Oxytocin signaling pathway MYLK2,GUCY1A3,CAMK2D,PPP3CB,PPP1R12C,MEF2C,MYL9,PLCB3,MAPK1,RAF1
    Fc epsilon RI signaling pathway IL4,IL3,KRAS,MAP2K3,PIK3CA,AKT2,MAP2K7,FYN,GRB2,RAC3
    Choline metabolism in cancer SP1,SLC22A3,PRKCB,CHKB,SLC22A5,PLCG1,AKT2,RAF1,WASF3,PDGFD
    Phospholipase D signaling pathway RHEB,TSC1,KRAS,FYN,PDGFRA,CYTH4,AGPAT5,ARF6,PLCB4,DGKD
    alpha-Linolenic acid metabolism PLA2G3,ACAA1A,PLA2G4F,ACAA1,PLA2G2F,ACOX3,PLA2G12B,PLA2G1B,PLA2G2D,PLA2G5

    Protein Function

    PLA2G4A has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipase A2 activity,calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4A itself. We selected most functions PLA2G4A had, and list some proteins which have the same functions with PLA2G4A. You can find most of the proteins on our site.

    Function Related Protein
    lysophospholipase activity PLA2G15,LYPLAL1,PLA2G4F,Cel,LGALS13,ASPG,PLB1,PNPLA6,PLA2G4B,PLA2G4AA
    phospholipase A2 activity ABHD3,PLA2G2D,PLA2G6,PLA2G4D,PLB1,PLA2G2A,PRDX6,LCAT,PLA2G4AA,PLA2G2F
    calcium-dependent phospholipase A2 activity PLA2G4F,PLA2G5,PLA2G1B,PLA2G4B,PLA2G2A,PLA2G12A,PLA2G3
    calcium ion binding NCS1B,CCBE1,HEG,DST,CAPN11,SYTL1,PCDHGC5,SGCA,SYT1,CLGN
    calcium-dependent phospholipid binding CPNE1,SYT17,PLA2G4B,ANXA3A,ANXA10,ANXA1B,TC2N,C2CD4B,SYT3,ANXA4

    Interacting Protein

    PLA2G4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G4A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G4A.

    ELF3;pi3p;Ccdc9;MYC;Eif3e

    Resources

    Research Area

    Acute Phase Proteins
    Inflammatory Mediators
    Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway
    Fatty Acid Catabolism

    References

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