PI4KA
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Official Full Name
phosphatidylinositol 4-kinase, catalytic, alpha -
Overview
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene. -
Synonyms
PI4KA;phosphatidylinositol 4-kinase, catalytic, alpha;PIK4CA;phosphatidylinositol 4-kinase alpha;PI4K ALPHA;pi4K230;PI4-kinase alpha;ptdIns-4-kinase alpha;phosphatidylinositol 4-kinase 230;phosphatidylinositol 4-kinase, type III, alpha;PI4K-ALPH
Recombinant Proteins
- Human
- Rat
- Insect Cell
- E.coli
- Sf9 Insect Cell
- Wheat Germ
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PI4KA-161H |
Active Recombinant Human PI4KA protein, GST-tagged
|
Insect Cell | Human | GST | ||
| PI4KA-1700H | Recombinant Human PI4KA, His-tagged | E.coli | Human | His | C-term-300aa | |
| PI4KA-117H | Recombinant Human PI4KA, GST-tagged | Sf9 Insect Cell | Human | GST |
|
|
| PI4KA-30331TH | Recombinant Human PI4KA | Wheat Germ | Human | Non | 110 amino acids |
|
| PI4KA-4439R | Recombinant Rat PI4KA Protein | Mammalian Cell | Rat | His |
|
|
| PI4KA-3207HCL | Recombinant Human PI4KA 293 Cell Lysate | HEK293 | Human | Non |
|
|
| PI4KA-1701H | Recombinant Human PI4KA protein, His-GST-tagged | E.coli | Human | His&GST | Met1~Trp300 |
|
| PI4KA-4099R | Recombinant Rat PI4KA Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| PI4KA-4099R-B | Recombinant Rat PI4KA Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
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| PI4KA-4905H | Recombinant Human PI4KA Protein (Met1-Tyr300), N-GST tagged | E.coli | Human | GST | Met1-Tyr300 |
|
Involved Pathway
PI4KA involved in several pathways and played different roles in them. We selected most pathways PI4KA participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PI4KA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | PIK3CD,MTMR7B,PLCB3,MTM1,PIP5K1C,INPPL1,PIK3R3,PLCB2,MTMR7A,PIK3R1 |
| Inositol phosphate metabolism | PIK3CG,CDIPT,PI4K2A,INPP4A,PTEN,PLCB1,NUDT11,PIP5K1AB,PIP4K2C,PIP5K1B |
| Metabolic pathways | AMPD3B,MTM1,UGT1A9,PPT1,EXT1C,CYP3A25,POLR3K,CYP3A5,ATP5G3B,NDUFA1 |
Protein Function
PI4KA has several biochemical functions, for example, 1-phosphatidylinositol 4-kinase activity,ATP binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PI4KA itself. We selected most functions PI4KA had, and list some proteins which have the same functions with PI4KA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PGK2,NTRK2B,MAP3K10,CARNS1,NEK7,IGHMBP2,TP53,ABCG5,GM4922,NTRK1 |
| protein binding | SERPINF2,ASB6,PSMD11,BOLA1,EIF2B5,BCKDHA,FREM2,GAGE1,TP53BP1,CDKN1A |
| 1-phosphatidylinositol 4-kinase activity | PI4K2A,PI4KAA,PI4KB,PI4K2B,PI4KAB |
Interacting Protein
PI4KA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PI4KA here. Most of them are supplied by our site. Hope this information will be useful for your research of PI4KA.
q99ib8-pro_0000045602;p27958-pro_0000037576;VCAM1;q9wmx2-pro_0000037551;TNNT1;purL;dnaJ2
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