PI3
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Official Full Name
peptidase inhibitor 3, skin-derived -
Overview
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008] -
Synonyms
PI3;peptidase inhibitor 3, skin-derived;ESI;WAP3;SKALP;WFDC14;cementoin;elafin;PI-3;trappin-2;pre-elafin;protease inhibitor WAP3;elastase-specific inhibitor;skin-derived antileukoproteinase;WAP four-disulfide core domain 14;WAP four-disulfide core domain protein 14;protease inhibitor 3, skin-derived (SKALP)
Recombinant Proteins
- Human
- Rhesus macaque
- E.coli
- Insect Cells
- HEK293
- Mammalian Cells
- Human Cells
- Yeast
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
- His&SUMO
Involved Pathway
PI3 involved in several pathways and played different roles in them. We selected most pathways PI3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PI3 has several biochemical functions, for example, endopeptidase inhibitor activity,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PI3 itself. We selected most functions PI3 had, and list some proteins which have the same functions with PI3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase inhibitor activity | SPINK2,C3,PSMF1,A1i3,A2ML,ITIH2,C5,SERPINF2,PCSK1N,CST14B.1 |
| serine-type endopeptidase inhibitor activity | COL7A1,SERPINA3K,ITIH3A,SPINK3,SERPINI2,SERPINC1,SERPINI1,SPINLW1,SERPINA6,WFDC8 |
Interacting Protein
PI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PI3.
CELA1
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References
- Kobayashi, S; Yamashita, T; et al. Hypoxia-inducible factor-3 alpha promotes angiogenic activity of pulmonary endothelial cells by repressing the expression of the VE-cadherin gene. GENES TO CELLS 20:224-241(2015).
- Green, CJ; Fraser, ST; et al. Insulin-like growth factor 1 increases apical fibronectin in blastocysts to increase blastocyst attachment to endometrial epithelial cells in vitro. HUMAN REPRODUCTION 30:284-298(2015).
