PHLDA2
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Official Full Name
pleckstrin homology-like domain, family A, member 2 -
Overview
This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. -
Synonyms
PHLDA2;pleckstrin homology-like domain, family A, member 2;TSSC3, tumor suppressing subtransferable candidate 3;pleckstrin homology-like domain family A member 2;BWR1C;HLDA2;IPL;Beckwith Wiedemann syndrome chromosome region 1 candidate protein C;Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein;BRW 1C;BRW1C;BWR 1C;HLDA 2;Imprinted in placenta and liver;Imprinted in placenta and liver protein;p17 Beckwith Wiedemann region 1C;p17 BWR1C;p17-Beckwith-Wiedemann region 1 C;p17-BWR1C;PHLA2_HUMAN;PHLDA 2;Pleckstrin homology like domain family A member 2;TSSC 3;Tumor suppressing STF cDNA 3 protein;Tumor suppressing subchromosomal transferable fragment candidate gene 3 protein;Tumor suppressing subchromosomal transferable fragment cDNA 3;Tumor suppressing subtransferable candidate 3;Tumor supressing STF cDNA 3;Tumor-suppressing STF cDNA 3 protein;Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein;OTTHUMP00000012603;tumor-supressing STF cDNA 3;p17-Beckwith-Wiedemann region 1C;tumo;TSSC3
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PHLDA2 involved in several pathways and played different roles in them. We selected most pathways PHLDA2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PHLDA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PHLDA2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PHLDA2 itself. We selected most functions PHLDA2 had, and list some proteins which have the same functions with PHLDA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
PHLDA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHLDA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHLDA2.
pi3p;Cenpe;Kctd5;SUCO
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