PHF1
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Official Full Name
PHD finger protein 1 -
Overview
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PHF1;PHD finger protein 1;MTF2L2;hPCl1;polycomb-like protein 1;PCL1;PHF2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHF1-1679H | Recombinant Human PHF1, His-tagged | E.coli | Human | His | 1-351aa | |
| PHF1-12714M | Recombinant Mouse PHF1 Protein | Mammalian Cell | Mouse | His |
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| PHF1-30328TH | Recombinant Human PHF1 | Wheat Germ | Human | Non | 99 amino acids |
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| PHF1-3403R | Recombinant Rhesus monkey PHF1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| PHF1-1344HCL | Recombinant Human PHF1 cell lysate | Human | Non |
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| PHF1-3221R | Recombinant Rhesus Macaque PHF1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| PHF1-3221R-B | Recombinant Rhesus Macaque PHF1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| PHF1-6682M | Recombinant Mouse PHF1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PHF1-6682M-B | Recombinant Mouse PHF1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PHF1 involved in several pathways and played different roles in them. We selected most pathways PHF1 participated on our site, such as Epigenetic regulation of gene expression,Gene Expression,PRC2 methylates histones and DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PRC2 methylates histones and DNA | JARID2B,MTF2,JARID2,PHF19,AEBP2 |
| Gene Expression | TRMT1,SF3A3,TYW1,ZNF584,ZIK1,COX8A,PDCD7,JUNB,ZNF750,PPARAA |
| Epigenetic regulation of gene expression | SUZ12B,DNMT3B,SAP30L,TAF1A,SUDS3,DNMT1,RRP8,DNMT3L,AEBP2,TAF1B |
Protein Function
PHF1 has several biochemical functions, for example, methylated histone binding,protein binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF1 itself. We selected most functions PHF1 had, and list some proteins which have the same functions with PHF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| methylated histone binding | CBX4,CHD8,RBBP5,CDYL2,GLYR1,CHD1,CBX8,ING5,L3MBTL2,SUZ12 |
| protein binding | ZNF18,VPS36,LY96,YY1A,ZFYVE16,ZNF26,DLAT,AVPR1A,ATF2,SQSTM1 |
| transcription factor activity, sequence-specific DNA binding | HOXB4,ZFP110,FOXO3B,ZNF155,KCNA3,TTC4,ZNF286A,FOXJ1B,ESR1,NFIL3 |
| zinc ion binding | MAN2C1,ZRANB1B,BRF1,NRD1B,ZRANB3,ZCCHC4,PDLIM7,MYLIP,MORC3,PRKCG |
Interacting Protein
PHF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF1.
TFCP2;RBPMS;TRIM23;VAC14;CALCOCO2;NAB2
Resources
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References
- Ittner, A; Bertz, J; et al. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. JOURNAL OF NEUROCHEMISTRY 132:135-145(2015).
- Ali, RH; Al-Safi, R; et al. Molecular characterization of a population-based series of endometrial stromal sarcomas in Kuwait. HUMAN PATHOLOGY 45:2453-2462(2014).
