PFDN4
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Official Full Name
prefoldin subunit 4 -
Overview
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. -
Synonyms
PFDN4;prefoldin subunit 4;prefoldin 4;C 1;C1;PFD4;Protein C1;protein C-1
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PFDN4 involved in several pathways and played different roles in them. We selected most pathways PFDN4 participated on our site, such as Chaperonin-mediated protein folding,Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFDN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | EIF5A2,SSPO,VBP1,ADAMTSL4,NOP56,NAPAB,F9B,CGB5,NSFA,RNF2 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | PFDN6,PFDN2,TUBB4B,CCT7,PFDN5,TUBA1B,CCT5,VBP1,TUBB4A,TUBA3D |
| Protein folding | TBCB,FBXL5,FBXW5,FKBP9,ARL2,CCT7,PFDN2,SERPINA7,FBXW9,TBCC |
| Chaperonin-mediated protein folding | KIFC3,CCT2,FBXW9,FBXL5,CCT8,TUBA1B,TUBB4B,FBXW5,PFDN6,CCT5 |
| Prefoldin mediated transfer of substrate to CCT/TriC | PFDN6,CCT6A,PFDN5,CCT7,VBP1,PFDN1,PFDN2 |
Protein Function
PFDN4 has several biochemical functions, for example, chaperone binding,protein binding,unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFDN4 itself. We selected most functions PFDN4 had, and list some proteins which have the same functions with PFDN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chaperone binding | VWF,ERP29,SYVN1,TBCA,SOD1,ATP1A3,TP53,ATP1A2,SLC25A17,FGB |
| unfolded protein binding | DNAJA4,DNAJB1A,HSPD1,GRPEL1,CRYAB,CALR3B,RP2,HSPA2,PPIA,PFDN2 |
| protein binding | DOCK4,JMY,KLHDC5,GRM2,SCYL2,NUP205,TMED1,RPP25L,TLDC2,LMNA |
Interacting Protein
PFDN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFDN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFDN4.
VBP1;PRPF4;EIF1B;TUBA3E;MAP3K3;SPATA2;Pfdn2;Vbp1;MAPK7
Resources
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References
- Takano, M; Tashiro, E; et al. Prefoldin prevents aggregation of alpha-synuclein. BRAIN RESEARCH 1542:186-194(2014).
- de Diego, RP; Ortiz-Lombardia, M; et al. Crystallization and preliminary X-ray diffraction analysis of the beta subunit Yke2 of the Gim complex from Saccharomyces cerevisiae. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 64:501-503(2008).
