PFDN2
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Official Full Name
prefoldin subunit 2 -
Overview
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. -
Synonyms
PFDN2;prefoldin subunit 2;prefoldin 2;OTTHUMP00000029707;PFD2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PFDN2 involved in several pathways and played different roles in them. We selected most pathways PFDN2 participated on our site, such as Chaperonin-mediated protein folding,Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFDN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein folding | TBCB,TBCA,FBXW5,TBCE,NOP56,PFDN5,TBCD,FBXL5,PFDN1,FBXW2 |
| TNF-alpha/NF-kB Signaling Pathway | DCAF7,G3BP2,AKAP8,ZFAND5,COPS3,SMARCB1,PEG3,DPF2,TXLNA,KPNA6 |
| Prefoldin mediated transfer of substrate to CCT/TriC | VBP1,CCT7,PFDN5,PFDN6,PFDN1,CCT6A,PFDN4 |
| Metabolism of proteins | EIF5,CNIH,ADAMTS10,SMC6,GAS6,TOMM22,EEF1B2,CNIH3,FKBP14,SAMM50 |
| Chaperonin-mediated protein folding | CCT3,TUBA3D,FBXL5,TUBB4A,FBXW9,CCT5,KIFC3,FBXW4,PFDN6,FBXW5 |
| Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding | CCT7,TUBA3D,CCT4,CCT3,TUBB4A,VBP1,PFDN1,PFDN4,CCT2,TUBB4B |
Protein Function
PFDN2 has several biochemical functions, for example, protein binding,protein binding involved in protein folding,unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFDN2 itself. We selected most functions PFDN2 had, and list some proteins which have the same functions with PFDN2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CALR,USF2,CLEC4G,CHN2,FOXH1,TTC23L,FOXP3,GLDN,RNF144B,WASF1 |
| unfolded protein binding | MKKS,CCT7,DNAJA2,HSPA8,RUVBL2,LRPAP1,ERLEC1,SPG7,NDUFAF1,CCT2 |
| protein binding involved in protein folding | CD74,HSPA1A,CALR3,PFDN1,DNAJB8,CALR,HSPA1B,CLGN,RIC3,PDCL3 |
Interacting Protein
PFDN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFDN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PFDN2.
URI1;f_hcvh;PPP1CC;RPAP3;GNB5;POLR3A;EIF1B;GTF2F2;MCC;VHL;EIF6;ARF6;Tubb4b;IKBKE
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References
- Horejsi, Z; Takai, H; et al. CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability. MOLECULAR CELL 39:839-850(2010).
- Lee, HN; Park, SH; et al. Proteomic profiling of tumor-initiating cells in HT-29 human colorectal cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 427:171-177(2012).
