PEX3
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Official Full Name
peroxisomal biogenesis factor 3 -
Overview
The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). -
Synonyms
PEX3;peroxisomal biogenesis factor 3;Peroxisomal assembly protein PEX3;TRG18;peroxin-3;transformation-related protein 18
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mus musculus
- Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster)
- Macaca fascicularis
- Kluyveromyces lactis
- S.cerevisiae
- Bovine
- Dictyostelium Discoideum
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- His&Myc
- His&Fc&Avi
Involved Pathway
PEX3 involved in several pathways and played different roles in them. We selected most pathways PEX3 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | CRATB,ACOX2,HSD17B4,NUDT12,PEX5,ABCD1,ACSL1,PEX19,PEX12,MLYCD |
Protein Function
PEX3 has several biochemical functions, for example, amino acid transmembrane transporter activity,lipid binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEX3 itself. We selected most functions PEX3 had, and list some proteins which have the same functions with PEX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TRIM22,DPYSL4,MAP4K4,TRIP12,C4orf19,ZNF643,TAF13,ISOC2,BOK,COL6A5 |
| lipid binding | APOL6,FABP1A,RASGRP2,ACBD5A,ACOT11,RBP2A,PPARA,BPIFB2,SH3GL2,APOA2 |
| protein dimerization activity | NEUROG1,TFAP2B,ATOH1B,MYCB,HPSE,ZBED6,MYCL1,AHR1A,ASCL3,EBF2 |
| amino acid transmembrane transporter activity | SLC7A6,SLC7A5,SLC38A6,SLC38A10,SLC38A4,SLC6A16B,SLC7A2,SLC38A5,SLC38A2,SLC6A20A |
Interacting Protein
PEX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEX3.
PEX19
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