PEPD
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Official Full Name
peptidase D -
Overview
This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PEPD;peptidase D;xaa-Pro dipeptidase;prolidase;MGC95081;Imidodipeptidase;MGC10905;Pep 4;Pep4;PEPD_HUMAN;Peptidase 4;Proline dipeptidase;X pro dipeptidase;X-Pro dipeptidase;aminoacyl-L-proline hydrolase
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PEPD involved in several pathways and played different roles in them. We selected most pathways PEPD participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PEPD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PEPD has several biochemical functions, for example, aminopeptidase activity,dipeptidase activity,manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEPD itself. We selected most functions PEPD had, and list some proteins which have the same functions with PEPD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metallocarboxypeptidase activity | CPB1,AGBL1,CPE,CPDB,AGTPBP1,CPA3,FOLH1,CPB2,CPZ,CPM |
| aminopeptidase activity | METAP1,CTSL2,TPP2,XPNPEP2,DNPEP,ENPEP,LAP3,METAP2B,TRHDE,DPP9 |
| dipeptidase activity | FOLH1,DPEP3,NAALAD2,DPEP2,CNDP1,SCRN2,SCRN1,SCRN3,CNDP2,NAALADL1 |
| protein binding | RWDD2B,SMAD6,FOXP1,MDH1,NCL,UBLCP1,ACMSD,CECR2,HSP90B1,USP49 |
| manganese ion binding | PPM1AA,ATP2C1,MTPAP,PPM1NB,PAPOLA,FEN1,B4GALT1,ABL1,LAP3,IMPA1 |
Interacting Protein
PEPD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEPD here. Most of them are supplied by our site. Hope this information will be useful for your research of PEPD.
TERF1;PKM;SPP1;ATXN1;glnQ;tig;comEA;q81mj8_bacan;acnA;q8cl08_yerpe
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References
- Lillvis, JH; Kyo, Y; et al. Analysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19. BMC MEDICAL GENETICS 12:-(2011).
- Wang, TY; Chen, YC; et al. Expression and characterization of the biofilm-related and carnosine-hydrolyzing aminoacylhistidine dipeptidase from Vibrio alginolyticus. FEBS JOURNAL 275:5007-5020(2008).
