PDPK1
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Official Full Name
3-phosphoinositide dependent protein kinase-1 -
Overview
A hallmark of signal transduction pathways is the reversible phosphorylation of serine and threonine residues within specific sequences, or motifs, in target proteins. Specific signaling motifs include not only sequences that are recognized by protein kin -
Synonyms
PDPK1;3-phosphoinositide dependent protein kinase-1;3-phosphoinositide-dependent protein kinase 1;PDK1;PkB kinase;PkB-like 1;PkB kinase like gene 1;PRO0461;MGC20087;MGC35290
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Sf9 Insect Cell
- Insect Cell
- Mammalian Cell
- HEK293
- Insect (sf21)
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PDPK1 involved in several pathways and played different roles in them. We selected most pathways PDPK1 participated on our site, such as PPAR signaling pathway,FoxO signaling pathway,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | LAMA4,TLN1,FLT4,COL4A1,LAMC3,FN1A,COL5A1,HRAS,ACTN2B,PGF |
| Endometrial cancer | PIK3CB,GRB2,NRAS,TP53,AXIN1,APC2,CCND1,MLH1,PIK3R2,AKT2 |
| Hepatitis C | RIPK1,CLDN16,IRF3,GSK3B,CLDN9,TLR3,CLDN17,IKBKE,OAS1A,RAF1 |
| Toxoplasmosis | HLA-DPB1,IL10RB,GNAI2,MAPK8,TNF,HLA-DOB,MYD88,LDLR,CD40,HLA-DRB3 |
| Insulin resistance | INSR,PPARGC1A,MTOR,PIK3CA,PPP1CC,MGEA5,INSRA,PPP1R3CB,PPP1CBL,GYS1 |
| mTOR signaling pathway | PIK3R3A,MAPK1,RPS6KA2,BRAF,RPS6KB1B,EIF4E2RS1,RICTOR,MLST8,ULK3,PIK3R3B |
| Fc epsilon RI signaling pathway | FCER1A,KRAS,RAC1,PIK3CB,PIK3R2,IL5,FCER1G,RAF1,MAPK9,PLA2G4D |
| Choline metabolism in cancer | PDGFA,HIF1A,PLA2G4B,MAPK1,PCYT1A,PPAP2C,MAPK9,GPCPD1,DGKE,RHEB |
| Thyroid hormone signaling pathway | PRKCA,MED13,MED12,WNT4,PIK3R1,FOXO1,DIO2,PIK3CD,SLCO1C1,HIF1A |
Protein Function
PDPK1 has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase activity,ATP binding,insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDPK1 itself. We selected most functions PDPK1 had, and list some proteins which have the same functions with PDPK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NLRC4,ACTB1,TDRD9,UCKL1A,NTRK2,PKZ,CNTN1B,GLYCTK,PEX1,DYNC2H1 |
| insulin receptor binding | DOK2,DOK1B,IGF2,PTPN11,PTPN1,ENPP1,DOK7,PHIP,PIK3R1,SHC1 |
| phospholipase activator activity | CCL8,CCL5,GM2A,CCL3,APOC2,ARHGAP6 |
| protein kinase binding | SYN1,KCNQ3,GCSAM,CALM3,CCNA2,PGAM1,CD24,HIF1A,RICTOR,IL12RB2 |
| protein binding | AKT3,CTNNAL1,LOXL2,ETV7,KXD1,DUSP15,COIL,RHOXF2,CALCR,SETMAR |
| phospholipase binding | NEFL,SERPINB1A,DGKQ,Pla2r1,CALM1,LMNB1,PARK2,WAS,SNCA,CALM2 |
| protein serine/threonine kinase activity | MAP2K2,BCR,PRKCBA,TESK2,SLC14A2,PRKCQ,PAK1,MOK,TLK1B,NEK5 |
| 3-phosphoinositide-dependent protein kinase activity | ALPK2 |
Interacting Protein
PDPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDPK1.
AKT1;YWHAQ;PPP2R2B;APBB3;CSK;SGK1;PTPRC
Resources
Research Area
Apoptosis Intracellular KinasesIntracellular Kinases in the Akt Pathway
Growth Hormone/IGF-I Axis
Intracellular Signaling Molecules in Angiogenesis
Related Services
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References
- Wong, VVT; Nissom, PM; et al. Zinc as an insulin replacement in hybridoma cultures. BIOTECHNOLOGY AND BIOENGINEERING 93:553-563(2006).
- Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
