PDK2
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Official Full Name
pyruvate dehydrogenase kinase, isozyme 2 -
Overview
This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
PDK2;pyruvate dehydrogenase kinase, isozyme 2;pyruvate dehydrogenase kinase, isoenzyme 2;PDHK2;pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Sf9 Insect Cell
- Insect Cell
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Insect (sf21)
- His
- GST
- His&T7
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PDK2 involved in several pathways and played different roles in them. We selected most pathways PDK2 participated on our site, such as B Cell Receptor Signaling Pathway,Metabolism,Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | OR7D2,STRAP,CXCL11.8,F11R.2,CLIP3,GPR4,ARHGAP1,GMIP,AKAP13,SOX32 |
| The citric acid (TCA) cycle and respiratory electron transport | SURF1,LRPPRC,C20orf7,C2orf56,NDUFAF2,PDK3,TACO1,SLC25A27,D2HGDH,UCP3 |
| B Cell Receptor Signaling Pathway | BLK,LAT2,TTC6,GSK3AB,KRAS,DOK1,CDK6,MAPK3,CDK2,MAPK4 |
| Pyruvate metabolism | HAGHL,ALDH3A2A,SLC16A8,MDH1,FH,GRHPRA,PKMB,DLDH,LDHBB,ALDH7A1 |
| Signaling by Retinoic Acid | RDH13,PDK2B,SDR16C5,CRABP2,CRABP2A,DHRS3A,DHRS9,RDH14A,PDK4,RDH10 |
| Regulation of pyruvate dehydrogenase (PDH) complex | PDK3B,PDPR,PDP2,PDK2B,PDK4,PDP1,PDK3 |
| Metabolism | CYP2D6,CYP26A1,CHST9,AKR1C4,SULT1ST5,GSTK1,ACOT9.2,CYP2N13,NUBP1,OAZ2 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | PDK3,PDP1,PDK2B,PDP2,PDPR,ADHFE1,PDK3B,MPC1,BRP44,SLC16A8 |
Protein Function
PDK2 has several biochemical functions, for example, ATP binding,protein homodimerization activity,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK2 itself. We selected most functions PDK2 had, and list some proteins which have the same functions with PDK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | HIF1AN,G6PDX,PDGFA,G6PD,KLHL7,SLC30A8,USF1,TCF3,STUB1,GCH1 |
| ATP binding | UBE2D1A,MTPAP,MCM5,NMNAT2,IRAK4,NADSYN1,NEK10,TNIK,MAPK8B,MVD |
| pyruvate dehydrogenase (acetyl-transferring) kinase activity | PDK3,PDK1,PDK4 |
| protein kinase activity | STK17B,CDKL3,PDPK1B,CSNK1D,CHEK1,PRKAB1,TBK1,CASKB,AKT2L,JAK2A |
Interacting Protein
PDK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK2.
HTT;ISOC2;HIC2;VSIG4;Pkd1;CTTN;PDK1;Hdac6
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References
- Seidu, MA; Adams, AR; et al. Immunoreactivity of some epitopes in longtime inappropriately stored paraffin-embedded tissues. JOURNAL OF HISTOTECHNOLOGY 36:59-64(2013).
- Liu, J; Lu, L; et al. Regulation of The Phosphorylation of Yeast Protein Kinase Sch9 Under Environmental Changes and During Chronological Aging. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 41:192-201(2014).
