PDIA3
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Official Full Name
protein disulfide isomerase family A, member 3 -
Overview
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008] -
Synonyms
PDIA3;protein disulfide isomerase family A, member 3;P58;ER60;ERp57;ERp60;ERp61;GRP57;GRP58;PI-PLC;HsT17083;HEL-S-269;HEL-S-93n;protein disulfide-isomerase A3;ER protein 57;ER protein 60;phospholipase C-alpha;58 kDa microsomal protein;disulfide isomerase ER-60;endoplasmic reticulum P58;58 kDa glucose-regulated protein;glucose regulated protein, 58kDa;epididymis secretory protein Li 269;protein disulfide isomerase-associated 3;endoplasmic reticulum resident protein 57;endoplasmic reticulum resident protein 60;epididymis secretory sperm binding protein Li 93n
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
- His&Myc
- Flag
Involved Pathway
PDIA3 involved in several pathways and played different roles in them. We selected most pathways PDIA3 participated on our site, such as Protein processing in endoplasmic reticulum,Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDIA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | CTSB,KIR2DL4,TAP2,HLA-DOB,TAPBP,HLA-C,HLA-DOA,HSPA1B,HLA-E,Ctsl |
| Protein processing in endoplasmic reticulum | CUL1B,ERO1L,DNAJC5B,SAR1B,CAPN2B,CALR3B,UBE2D2L,EDEM1,FBXO6,DNAJB1B |
Protein Function
PDIA3 has several biochemical functions, for example, cysteine-type endopeptidase activity,disulfide oxidoreductase activity,phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDIA3 itself. We selected most functions PDIA3 had, and list some proteins which have the same functions with PDIA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein disulfide isomerase activity | PDIA4,ERO1LB,ITGB3,ERP44,QSOX1,GLRX2,ERO1L,PDIA6,PDIA2,TXNDC5 |
| phospholipase C activity | PLCG2,PLCB3,PLCG1,PLCB4,PLCE1,PLCL1,PLCH2,ADORA1,PLCB2 |
| disulfide oxidoreductase activity | TXNL1,TMX1,TXN,DNAJC10,COIL,PDIA2,GRX2 |
| protein binding | GP6,C16orf48,PALLD,MEA1,LENG1,YOD1,FAM86A,PAIP1,ZRSR2,FASLG |
| cysteine-type endopeptidase activity | Casp3,USP13,CTSLA,CASP9,ATG4D,Ctsl,CTSL.1,SFRP1,CASP6,CASP1 |
| poly(A) RNA binding | NGRN,ATP5A1,PPHLN1,WDR46,DBR1,JUN,PPIB,FAM32A,DDX54,PHF5A |
Interacting Protein
PDIA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDIA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDIA3.
ERO1L;CLU;STIM1;APP;TAP1;env;Edem3;AGRN
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References
- Doroudi, M; Schwartz, Z; et al. Membrane-mediated actions of 1,25-dihydroxy vitamin D3: A review of the roles of phospholipase A(2) activating protein and Ca2+/calmodulin-dependent protein kinase II. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 147:81-84(2015).
- Nemere, I; Garbi, N; et al. The 1,25D(3)-MARRS Receptor/PDIA3/ERp57 and Lifespan. JOURNAL OF CELLULAR BIOCHEMISTRY 116:380-385(2015).
