PDE3B

  • Official Full Name

    PDE3B phosphodiesterase 3B, cGMP-inhibited

  • Overview

    Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B

  • Synonyms

    PDE3B;phosphodiesterase 3B, cGMP-inhibited;cGMP-inhibited 3,5-cyclic phosphodiesterase B;HcGIP1;CGIP1;CGI-PDE B;cyclic nucleotide phosphodiesterase;cyclic GMP-inhibited phosphodiesterase B;cGIPDE1

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Mouse
  • E.coli
  • Sf9 Insect Cell
  • Mammalian Cell
  • HEK293
  • HEK293T
  • His
  • GST
  • Non
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
PDE3B-3492H Recombinant Human PDE3B protein, His-tagged E.coli Human His 321-670 aa
PDE3B-1526H Active Recombinant Human PDE3B, GST-tagged Sf9 Insect Cell Human GST 654 aa-end
PDE3B-2849C Recombinant Chicken PDE3B Mammalian Cell Chicken His
PDE3B-29932TH Recombinant Human PDE3B Human Non 592-1112 a.a.
PDE3B-4329R Recombinant Rat PDE3B Protein Mammalian Cell Rat His
PDE3B-474H Recombinant Human PDE3B, GST-tagged, Active Sf9 Insect Cell Human GST 654-end a.a.
Kit-1836 PDE3B Assay Kit I Non
Kit-1837 PDE3B Assay Kit II Non
PDE3B-3989R Recombinant Rat PDE3B Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PDE3B-3989R-B Recombinant Rat PDE3B Protein Pre-coupled Magnetic Beads HEK293 Rat
Pde3b-4744M Recombinant Mouse Pde3b Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
PDE3B-6370H Recombinant Human PDE3B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
PDE3B-742H Recombinant Human PDE3B Protein, MYC/DDK-tagged HEK293 Human Myc&DDK

    Involved Pathway

    PDE3B involved in several pathways and played different roles in them. We selected most pathways PDE3B participated on our site, such as Purine metabolism,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Progesterone-mediated oocyte maturation INS,MAPK13,CPEB1,AKT3A,MAPK3,INSB,MAPK12B,CDH1-A,MAD1L1,SPDYA
    cGMP-PKG signaling pathway NFATC3,PLCB2,ATP2A3,VDAC3,BNP,TRPC6,GNAI1,AGTR1A,PRKG2,RAF1
    cAMP signaling pathway VAV1,GPR81,Adcy4,GABBR2,BDNF,PIK3R3,VAV3,RELA,GLP1R,FSHR
    Purine metabolism POLE4,NME4,PDE6D,PDE3A,GC2,NT5C1AA,CECR1A,GUCY1B3,POLR2C,NT5C3B
    Renin secretion CLCA2,PLCB2,GUCY1B3,PRKACA,GNAI2,PTGER2,LOC100328615,PRKACG,REN2,ITPR3
    Insulin signaling pathway SOCS4,FLOT2A,SHC2,INSRA,PDPK1,G6PCA.1,PRKCZ,CALM1B,PIK3CG,MAPK3
    Regulation of lipolysis in adipocytes IRS4,AKT2,PIK3CD,GNAI2,TSHR,NPY,PTGS2,GNAI3,PTGER3,PRKG2

    Protein Function

    PDE3B has several biochemical functions, for example, 3,5-cyclic-nucleotide phosphodiesterase activity,cGMP-inhibited cyclic-nucleotide phosphodiesterase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3B itself. We selected most functions PDE3B had, and list some proteins which have the same functions with PDE3B. You can find most of the proteins on our site.

    Function Related Protein
    protein binding GGPS1,GSPT2,HIST1H3H,KCNJ6,CLSTN2,RPL5,FKBP4,GLS,TPX2,C1D
    3,5-cyclic-nucleotide phosphodiesterase activity PDE9A,PDE5A,PDE6D,PDE10A,PDE11A,PDE8B,PDE4D,PDE8A,PDE5AB
    metal ion binding MMP14A,ZNF207A,ZFP28,PDE5A,ENTPD7,PPAT,RAD50,CYB5B,ZIK1,ZNF843
    protein kinase B binding APPL1,PINK1,CCDC88A,TRAF6,BCL10,BAD,CDC37,RARA,ANKRD2
    cGMP-inhibited cyclic-nucleotide phosphodiesterase activity PDE3A,TDP2B,USB1

    Interacting Protein

    PDE3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3B.

    RAPGEF3;PIK3R6;PIK3CG

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