PDE3A
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Official Full Name
PDE3A phosphodiesterase 3A, cGMP-inhibited -
Overview
Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B -
Synonyms
PDE3A;phosphodiesterase 3A, cGMP-inhibited;cGMP-inhibited 3,5-cyclic phosphodiesterase A;CGI PDE;cyclic GMP-inhibited phosphodiesterase A;cAMP phosphodiesterase, myocardial cGMP-inhibited;CGI-PDE;CGI-PDE A;CGI-PDE-A;FLJ37884
Recombinant Proteins
- Rat
- Human
- E.coli
- Wheat Germ
- Mammalian Cells
- Sf9 Cells
- Insect Cells
- HEK293
- His&GST
- Non
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Pde3a-301R | Recombinant Rat Pde3a Protein, His/GST-tagged | E.coli | Rat | His&GST | Leu948~Leu1141 | |
| PDE3A-29931TH | Recombinant Human PDE3A | Wheat Germ | Human | Non | 108 amino acids |
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| PDE3A-4328R | Recombinant Rat PDE3A Protein | Mammalian Cells | Rat | His |
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| PDE3A-473H | Recombinant Human PDE3A, GST-tagged, Active | Sf9 Cells | Human | GST | 669-end a.a. |
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| PDE3A-7332H | Recombinant Human PDE3A, His & GST tagged | Insect Cells | Human | His&GST | 669-1141 a.a. |
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| PDE3A-001HCL | Recombinant Human PDE3A cell lysate | Insect Cells | Human | Non |
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| Kit-1834 | PDE3A Assay Kit | Non |
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| Kit-1835 | PDE3A TR-FRET Assay Kit | Non |
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| PDE3A-018H | Recombinant Human PDE3A Protein, His/GST-tagged | Insect Cells | Human | His&GST | 669-1141 |
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| PDE3A-01H | Recombinant Human PDE3A Protein, His/GST-tagged | Insect Cells | Human | His&GST | 669-1141 |
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| PDE3A-3988R | Recombinant Rat PDE3A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PDE3A-3988R-B | Recombinant Rat PDE3A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
PDE3A involved in several pathways and played different roles in them. We selected most pathways PDE3A participated on our site, such as Purine metabolism,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renin secretion | PDE1B,PRKG2,CALM4,CLCA1,AGTR1A,CALM3,GNAQ,GUCY1B3,CALM2,PRKACG |
| Purine metabolism | PDE4B,IMPDH2,GUK1A,POLR1D,GUCY2F,NT5C3A,URAD,TWISTNB,ENTPD2,POLR1E |
| cAMP signaling pathway | VAV1,CREB3L1,RRAS2,PIK3R1,RAC3,GLI1,HCN2,PLN,PIK3CD,ATP2A2 |
| cGMP-PKG signaling pathway | ATP1B4,CREB3L2,ROCK2,KCNMB3,ATF4,ATP1A1,AKT2,ROCK1,GATA4,CALML5 |
Protein Function
PDE3A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity,cAMP binding,cGMP-inhibited cyclic-nucleotide phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3A itself. We selected most functions PDE3A had, and list some proteins which have the same functions with PDE3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3,5-cyclic-AMP phosphodiesterase activity | PDE1B,USB1,PDE7A,PDE4A,PDE8B,PDE4C,PDE4D,PDE8A,PDE7B,PDE4B |
| cGMP-inhibited cyclic-nucleotide phosphodiesterase activity | TDP2B,PDE3B,USB1 |
| metal ion binding | HAGH,ARFGAP2,VAV3B,ZKSCAN4,PPM1BA,MBNL2,CNBPA,POLD1,TAX1BP1,PLA2G3 |
| cAMP binding | HCN4,PDE10A,PDE4A,HCN2,PDE2A,RAPGEF4,CNGA2,CNMPD1,PDE4D,PDE11A |
Interacting Protein
PDE3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3A.
YWHAZ;Pcdh1;Cenpe;WDR62;HSPA5;BMH1;KIF11;Ccser2;CCDC88A;Cep44;Kctd5;Spred2;TUBA1C;Cenph;FBXO7
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References
- Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
- Proenca-Ferreira, R; Franco-Penteado, CF; et al. Increased adhesive properties of platelets in sickle cell disease: roles for alpha(IIb)beta(3)-mediated ligand binding, diminished cAMP signalling and increased phosphodiesterase 3A activity. BRITISH JOURNAL OF HAEMATOLOGY 149:280-288(2010).
