PCSK2
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Official Full Name
proprotein convertase subtilisin/kexin type 2 -
Overview
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014] -
Synonyms
PCSK2;proprotein convertase subtilisin/kexin type 2;PC2;NEC2;SPC2;NEC 2;NEC-2;neuroendocrine convertase 2;prohormone convertase 2;KEX2-like endoprotease 2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- CHO
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PCSK2 involved in several pathways and played different roles in them. We selected most pathways PCSK2 participated on our site, such as Insulin processing,Metabolism of proteins,Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin processing | CPE,KIF5A,SLC30A8,RAB27A,EXOC5,KIF5B,EXOC8,EXOC1,SLC30A5,SLC30A6 |
| Peptide hormone metabolism | CPB1,CPB2,GPR119,CDX2,EXOC8,DPP4,INHA,GPR120,ATP6AP2,MBOAT4 |
| Metabolism of proteins | FBXW4,FBXL5,EEF1D,PFDN4,TRAPPC6A,TIMM9,ARSH,MAN1A2,MAN1B1,NSFB |
Protein Function
PCSK2 has several biochemical functions, for example, protein binding,protein complex binding,serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK2 itself. We selected most functions PCSK2 had, and list some proteins which have the same functions with PCSK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | PRSS2,FAP,TPSAB1,PARL,KLK9,PRSS48,PCSK4,IMMP2L,GZMK,CLPP |
| protein binding | RHOT1,CORO6,PCBP2,RAP1GAP,TPD52L3,PIANP,STK3,PICK1,RAB33B,DPYD |
| protein complex binding | CD2AP,RPAIN,PROS1,SKAP1,SLC9A3R1,RARB,KIF11,RAP1A,KRAS,CDKN1B |
Interacting Protein
PCSK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK2.
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References
- Berger, JM; Vaillant, N; et al. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. ATHEROSCLEROSIS 239:252-259(2015).
- de Keyser, CE; Becker, ML; et al. The rs13064411 polymorphism in the WDR52 gene, associated with PCSK9 levels, modifies statin-induced changes in serum total and LDL cholesterol levels. PHARMACOGENETICS AND GENOMICS 25:134-142(2015).
