PCCA
-
Official Full Name
propionyl CoA carboxylase, alpha polypeptide -
Overview
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PCCA;propionyl CoA carboxylase, alpha polypeptide;propionyl Coenzyme A carboxylase, alpha polypeptide;propionyl-CoA carboxylase alpha chain, mitochondrial;PCCase subunit alpha;Propanoyl CoA:carbon dioxide ligase subunit alpha;Propionyl CoA carboxylase alpha chain;Propionyl CoA carboxylase alpha chain mitochondrial;Propionyl Coenzyme A Carboxylase Alpha Polypeptide;PCCase alpha subunit;pccA complementation group;propanoyl-CoA:carbon dioxide ligase alpha subunit
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- His&T7
- Non
- Myc&Flag
- His&Fc&Avi
- His&GST
- Myc&DDK
- Flag
Involved Pathway
PCCA involved in several pathways and played different roles in them. We selected most pathways PCCA participated on our site, such as Valine, leucine and isoleucine degradation,Glyoxylate and dicarboxylate metabolism,Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glyoxylate and dicarboxylate metabolism | GCSH,AGXTA,GRHPR,MDH2,GCSHB,ANI_1_2390104,ACAT1,MDH1AA,CS,GRHPRB |
| Propanoate metabolism | ACSS1,ACADM,PCCB,ACACB,DLDH,MCEE,MUT,ACSS2,BCKDHA,SUCLG2 |
| Metabolic pathways | GSS,ATP6V0A1A,PNP,ALDH9A1B,AGL,CEPT1,FASN,PLCB4,ST6GALNAC1,CMPK1 |
| Carbon metabolism | PKLR,ALDOCA,GPT,ANI_1_2390104,PHGDH,MDH2,ACSS2L,TKTB,DLAT,PGK1 |
| Valine, leucine and isoleucine degradation | OXCT2B,HIBADH,ALDH9A1B,ACADSB,AACS,AOX4,ALDH1B1,ACAA1A,HADHAA,ALDH3A2 |
Protein Function
PCCA has several biochemical functions, for example, ATP binding,biotin binding,biotin carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCCA itself. We selected most functions PCCA had, and list some proteins which have the same functions with PCCA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | PHB,HDAC1,ERN1,PRKCA,Slc4a2,HIST1H2AL,HIF1A,PICK1,THRB,LAMB1 |
| propionyl-CoA carboxylase activity | PCCB |
| biotin binding | HLCS,PC,MCCC1,AVR2,PCXB,PCXA |
| metal ion binding | ZNF705B,S100A10B,TRIM26,ZNF559,LMTK3,LNX2,ZBTB37,RNFT1,GUCA1B,YME1L1 |
| ATP binding | ATP1A1A.4,GM4922,ABCG2B,MYO6A,DGKAA,ABCD3,STK32A,MLH3,FIGNL1,EPHA2A |
| biotin carboxylase activity | PCXB,PCXA,ACACA,MCCC1,ACACB,PC |
Interacting Protein
PCCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCCA here. Most of them are supplied by our site. Hope this information will be useful for your research of PCCA.
PARP2;recB;BAG2;US11;IFIT1;PPP2R2B;EBNA-LP;SIRT4
Resources
Related Services
Related Products
References
- Muro, S; Perez, B; et al. Effect of PCCB gene mutations on the heteromeric and homomeric assembly of Propionyl-CoA carboxylase. MOLECULAR GENETICS AND METABOLISM 74:476-483(2001).
- Stadler, SC; Polanetz, R; et al. Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 334:939-946(2005).
