PCBP4
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Official Full Name
poly(rC) binding protein 4 -
Overview
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This genes protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. -
Synonyms
PCBP4;poly(rC) binding protein 4;poly(rC)-binding protein 4;alphaCP 4 protein;LIP4;LYST interacting protein;MCG10;RNA binding protein MCG10;Alpha CP4;rCbinding protein 4;alpha-CP4;LYST-interacting protein;CBP
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PCBP4 involved in several pathways and played different roles in them. We selected most pathways PCBP4 participated on our site, such as Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Direct p53 effectors | GDF15,DUSP1,ZNF385A,FDXR,CD82,EDN2,BNIP3L,BCL2L14,HIC1,CEBPZ |
Protein Function
PCBP4 has several biochemical functions, for example, DNA binding,RNA binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCBP4 itself. We selected most functions PCBP4 had, and list some proteins which have the same functions with PCBP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HIST1H2AK,SCXB,TIGD3,NR4A2A,GEN1,NR1H5,ZNF671,SYCP1,ZNF454,ZFP667 |
| poly(A) RNA binding | RPL28,RBM26,PLEC,ADARB2,WDR43,CELF2,PTCD1,ZNF622,NUDT16L1,FASTKD5 |
| RNA binding | RPL11,SNRNP70,DOM3Z,PABPC5,RPL14,RBM18,RDBP,SRSF1B,BRCA1,CWC15 |
Interacting Protein
PCBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCBP4.
PCBP1;RNF138;QKI;RBFOX1
Resources
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References
- Wong, BW; Kuchnio, A; et al. Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes. TRENDS IN BIOCHEMICAL SCIENCES 38:3-11(2013).
- Xia, M; He, H; et al. PCBP1 is required for maintenance of the transcriptionally silent state in fully grown mouse oocytes. CELL CYCLE 11:2833-2842(2012).
