PAX4
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Official Full Name
paired box 4 -
Overview
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008] -
Synonyms
PAX4;paired box 4;KPD;MODY9;paired box protein Pax-4;paired box gene 4;paired domain gene 4
Recombinant Proteins
- Mouse
- Human
- Rat
- Zebrafish
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PAX4-12393M | Recombinant Mouse PAX4 Protein | Mammalian Cell | Mouse | His |
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| PAX4-29532TH | Recombinant Human PAX4 | Wheat Germ | Human | Non | 97 amino acids |
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| PAX4-392H | Recombinant Human PAX4 Protein, His-tagged | E.coli | Human | His |
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| PAX4-4283R | Recombinant Rat PAX4 Protein | Mammalian Cell | Rat | His |
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| PAX4-8070Z | Recombinant Zebrafish PAX4 | Mammalian Cell | Zebrafish | His |
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| PAX4-3417HCL | Recombinant Human PAX4 293 Cell Lysate | HEK293 | Human | Non |
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| PAX4-3945R | Recombinant Rat PAX4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PAX4-3945R-B | Recombinant Rat PAX4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PAX4-6518M | Recombinant Mouse PAX4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| PAX4-6518M-B | Recombinant Mouse PAX4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
PAX4 involved in several pathways and played different roles in them. We selected most pathways PAX4 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Maturity onset diabetes of the young | HNF1A,HHEX,HES1,MAFA,FOXA2,INS2,PKLR,NKX6,ONECUT1,HNF4A |
Protein Function
PAX4 has several biochemical functions, for example, DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX4 itself. We selected most functions PAX4 had, and list some proteins which have the same functions with PAX4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NKX6-1,SOX15,ORC1L,RORAA,LBX1A,TBX10,NKX2.4A,HIST1H110,HMG20A,DMRT3A |
| RNA polymerase II distal enhancer sequence-specific DNA binding | HOXB5,NONO,NR5A2,ARX,CDX1,BACH1,SIX3,PROP1,SFPI1,NFE2L1 |
| transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding | ARX,MSC,BACH1,ZBTB16,PROP1,BACH2,GZF1 |
Interacting Protein
PAX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX4.
Resources
Research Area
Pancreatic Endoderm Cell MarkersPancreatic Progenitor Cell Transcription Factors
Hepatic and Pancreatic Progenitor Cell Transcription Factors
Endodermal Lineage Markers
Related Services
Related Products
References
- Bonnavion, R; Jaafar, R; et al. Both PAX4 and MAFA Are Expressed in a Substantial Proportion of Normal Human Pancreatic Alpha Cells and Deregulated in Patients with Type 2 Diabetes. PLOS ONE 8:-(2013).
- Lorenzo, PI; Moreno, CMJ; et al. Immunohistochemical assessment of Pax8 expression during pancreatic islet development and in human neuroendocrine tumors. HISTOCHEMISTRY AND CELL BIOLOGY 136:595-607(2011).
