PAK7

  • Official Full Name

    p21 protein (Cdc42/Rac)-activated kinase 7

  • Overview

    The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described

  • Synonyms

    PAK7;p21 protein (Cdc42/Rac)-activated kinase 7;PAK5;KIAA1264;MGC26232;OTTHUMP00000030260;p21(CDKN1A)-activated kinase 7;p21-activated kinase 7;p21CDKN1A-activated kinase 7;protein kinase PAK5;serine/threonine-protein kinase PAK7;EC 2.7.11.1

Recombinant Proteins

  • Human
  • Zebrafish
  • Rhesus macaque
  • Rat
  • Chicken
  • E.coli
  • Mammalian Cell
  • Sf9 Insect Cell
  • HEK293
  • GST
  • Non
  • His
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PAK7-1515H Recombinant Human PAK7, GST-tagged E.coli Human GST C-term-300aa
PAK7-20H Active Recombinant Human PAK7 E.coli Human Non
PAK7-12211Z Recombinant Zebrafish PAK7 Mammalian Cell Zebrafish His
PAK7-30672TH Recombinant Human PAK7 Human Non Full L.
PAK7-3293R Recombinant Rhesus monkey PAK7 Protein, His-tagged Mammalian Cell Rhesus macaque His
PAK7-382H Recombinant Human PAK7, GST-tagged, Active Sf9 Insect Cell Human GST
PAK7-4262R Recombinant Rat PAK7 Protein Mammalian Cell Rat His
PAK7-4283C Recombinant Chicken PAK7 Mammalian Cell Chicken His
PAK7-522H Recombinant Human P21 Protein (Cdc42/Rac)-Activated Kinase 7 E.coli Human Non 425-719 a.a.
PAK7-725H Recombinant Human PAK7, GST-His Sf9 Insect Cell Human GST 1-719 a.a.
PAK7-3452HCL Recombinant Human PAK7 293 Cell Lysate HEK293 Human Non
PAK7-3453HCL Recombinant Human PAK7 293 Cell Lysate HEK293 Human Non
PAK7-3111R Recombinant Rhesus Macaque PAK7 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PAK7-3111R-B Recombinant Rhesus Macaque PAK7 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PAK7-3924R Recombinant Rat PAK7 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PAK7-3924R-B Recombinant Rat PAK7 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    PAK7 involved in several pathways and played different roles in them. We selected most pathways PAK7 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway VEGFB,PLCG2,RGL1,CALML5,FGF18,KSR1,TBK1,FGF14,KITLG,RASSF5
    Focal adhesion COL11A2,PDPK1,LAMC1,AKT2L,RHOB,PPP1CAA,PTEN,FLNB,FLT1,MYL5
    ErbB signaling pathway MYCB,TGFA,CAMK2D1,PIK3R1,CAMK2B1,HRAS,PLCG1,SHC1,CBLB,ABL1
    T cell receptor signaling pathway PPP3R1,CD28,PIK3R1,MAP2K2,MUC1,CBLB,PPP3CA,CD8B1,PDCD1,FYN
    Axon guidance SEMA3D,PPP3R1,FGFR1B,EPHA2,RHOAE,PHB,ARHGEF28,NCK1,SEMA6D,EFNA3
    Regulation of Actin Cytoskeleton FGF5,RDX,PIP5K1B,TMSB4Y,ITGA5,PAK6,FGF20B,FGF8,PIP5K2,ITGB2L
    Renal cell carcinoma SOS1,PDGFB,MAPK1,HGF,NRAS,RAF1,CUL2,RAC1,GRB2,MET

    Protein Function

    PAK7 has several biochemical functions, for example, ATP binding,Rac GTPase binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK7 itself. We selected most functions PAK7 had, and list some proteins which have the same functions with PAK7. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CSNK1A1L,DHX57,ABCA3,HKDC1,TP53,C9orf96,GSK3AB,EPHA7,MTHFD1L,MYHC4
    Rac GTPase binding FLNA,RCC2,ARHGEF2,CDKL5,NOX1,CORO1C,PAK6,SRGAP3,DOCK7,NCF2
    protein serine/threonine kinase activity CAMK2D1,MAP3K9,PLK2B,ERN2,CHEK2,PAK1,SGK1,STK35,STK30,IRAK1

    Interacting Protein

    PAK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK7.

    PKM;4757996;S100A9;S100A7;RPA3;CCDC59;HIGD1A;CDC42;ARRB2

    PAK7 Related Signal Pathway

    Resources

    Research Area

    PAK (p21-activated Kinases)

    References

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