PAK3

  • Official Full Name

    p21 protein (Cdc42/Rac)-activated kinase 3

  • Overview

    PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.

  • Synonyms

    PAK3;p21 protein (Cdc42/Rac)-activated kinase 3;mental retardation, X linked 47 , MRX30, MRX47, p21 (CDKN1A) activated kinase 3;serine/threonine-protein kinase PAK 3;bPAK;hPAK3;PAK-3;beta-PAK;oligophrenin-3;p21-activated kinase 3;p21 (CDKN1A)-a

Recombinant Proteins

  • Human
  • Rat
  • Insect Cells
  • Sf9 Cells
  • Mammalian Cells
  • Sf21 Cells
  • HEK293
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PAK3-1354H Active Recombinant Human PAK3 protein, His-tagged Insect Cells Human His Met1-Arg544
PAK3-379H Recombinant Human PAK3, GST-tagged, Active Sf9 Cells Human GST
PAK3-4261R Recombinant Rat PAK3 Protein Mammalian Cells Rat His
PAK3-722H Recombinant Human PAK3, GST-His Sf9 Cells Human GST Full L. 1-544 a.a.
PAK3-517HCL Recombinant Human PAK3 cell lysate Insect Cells Human Non
PAK3-1104H Recombinant Human PAK3 Protein (M1-R559), Tag Free Insect Cells Human Non M1-R559
PAK3-1105H Recombinant Human PAK3 Protein (M1-R559), GST tagged Insect Cells Human GST M1-R559
PAK3-3520HF Active Recombinant Full Length Human PAK3 Protein, GST-tagged Sf21 Cells Human GST Full L. 1-544
PAK3-36H Recombinant Active Human PAK3 Protein (Full length), N-GST-tagged Sf9 Cells Human GST Full L. Full Length
PAK3-3923R Recombinant Rat PAK3 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PAK3-3923R-B Recombinant Rat PAK3 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    PAK3 involved in several pathways and played different roles in them. We selected most pathways PAK3 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway NRAS,PAK1,STAT5B,GAB1,PTK2AA,RAF1A,PIK3CD,SRC,PIK3CB,AKT3A
    Ras signaling pathway PIK3CG,FGF8,BCL2L1,PRKACA,GNB3,PLA2G10,FIGF,HTR7,GNB1,PDGFRB
    Focal adhesion MYL5,COL11A1A,IGF1,AASS,CHAD,ILK,LAMC1,MAPK1,PRKCG,PTK2AB
    Regulation of Actin Cytoskeleton FGFR2,DIAPH1,CD14,FGF12A,PAK7,PDGFB,RAF1,ARPC5L,GSNB,ITGA3B
    Renal cell carcinoma TGFA,AHA-1,ARNT,HGF,EP300,SOS1,PAK2,RAP1B,PIK3CG,SLC2A1
    T cell receptor signaling pathway MAPK11,PRKCQ,MAP3K7,PIK3CA,NRAS,PAK1,SOS1,OXSR1A,PPP3CB,NCK2
    Axon guidance SPNA2,PAK4,SDCBP,PTPRA,RND1L,DUSP5,SLIT3,EPHB4A,CFL2,DAB2IPB

    Protein Function

    PAK3 has several biochemical functions, for example, ATP binding,MAP kinase kinase activity,Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK3 itself. We selected most functions PAK3 had, and list some proteins which have the same functions with PAK3. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ZMYND10,ZNF365,TBL1XR1,COG8,C12orf40,MRPL45,RAN,SNAPC5,IKBKE,GPR177
    MAP kinase kinase activity MAP2K3,MAP3K20,SBK3,MAP3K14,MAP2K2,MAPKAPK5,MAP2K6,MAP2K1,MAP2K7,MAPK14
    Rac GTPase binding NOX1,PAK2A,SRGAP2,DOCK7,SRGAP2A,CDKL5,SRGAP3,EPS8,CAV1,SRGAP2B
    metal ion binding ZFP184,ARAF,ZNF75A,NDUFS7,ZFP422,CPEB1,ROCK2A,SOBP,ZNF583,ZDHHC14
    SH3 domain binding SH3BGRL2,EFS,WIPF3,REPS1,SHANK2,EVLB,PLSCR3,QKIA,ABI2,MICAL1
    ATP binding CHD4A,DDX19,RAD51C,PFKP,MYH7B,GRK5,CHST13,NAIP6,ORC4,NEK6
    protein serine/threonine kinase activity MAPK11,MAP3K8,MAP4K6,CSNK2A1,PRPF4B,RPS6KA3A,DSTYK,PRKCE,CAMK2G1,STK38

    Interacting Protein

    PAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK3.

    RAC1;CDC42;PLK1;CDC42;STK4

    PAK3 Related Signal Pathway

    Resources

    Research Area

    Intracellular Kinases in the Akt Pathway
    PAK (p21-activated Kinases)

    References

    • Kreis, P; Rousseau, V; et al. The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties. JOURNAL OF NEUROCHEMISTRY 106:1184-1197(2008).
    • McFawn, PK; Shen, L; et al. Calcium-independent contraction and sensitization of airway smooth muscle by p21-activated protein kinase. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 284:L863-L870(2003).

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