PA2G4
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Official Full Name
proliferation-associated 2G4, 38kDa -
Overview
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
PA2G4;proliferation-associated 2G4, 38kDa;EBP1;HG4-1;p38-2G4;proliferation-associated protein 2G4;erbB3-binding protein 1;ErbB-3 binding protein 1;ErbB3-binding protein Ebp1;cell cycle protein p38-2G4 homolog
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- GST
- Avi
- Fc
- DDK
- Myc
Involved Pathway
PA2G4 involved in several pathways and played different roles in them. We selected most pathways PA2G4 participated on our site, such as Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PA2G4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Coregulation of Androgen receptor activity | TGFB1I1,SVIL,ZMIZ1,CMTM2,KDM1A,TMF1,KDM4C,TCF4,KDM3A,NRIP1 |
Protein Function
PA2G4 has several biochemical functions, for example, DNA binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PA2G4 itself. We selected most functions PA2G4 had, and list some proteins which have the same functions with PA2G4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | H2-AB1,BAG4,CASC3,MAGEA2B,TRAF6,GPR19,USP13,SPOP,FZD5,NPLOC4 |
| protein binding | HP1BP3,CAP2,NSFL1C,FOXL2,APOBEC2A,CLNK,MAP3K14,FCGR2A,F2R,MYOZ1 |
| DNA binding | SMARCAD1,ZBED1,HOXC8A,TBX5A,ZNF483,ZIM2,GTF2IRD1,GPBP1L1,C14orf43,SP140 |
| transcription factor activity, sequence-specific DNA binding | MYNN,NR2F1,ZNF213,TAF6,GTF2H4,BHLHE22,RREB1,HOXD3A,EGR1,FOXO4 |
| poly(A) RNA binding | RBM12B1,BRIX1,SAP18,TWF2,MRPS28,UBA1,KCTD12,ZFP579,ATP5C1,C14orf21 |
Interacting Protein
PA2G4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PA2G4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PA2G4.
SIN3A;RB1;NCL;NPM1;SGK1;PIK3C2A;PDPK1;GBAS;AR;ERBB3;HLA-B
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