P2RX7
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Official Full Name
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 -
Synonyms
P2RX7;purinergic receptor P2X, ligand-gated ion channel, 7;P2X purinoceptor 7;ATP receptor;P2Z receptor;P2X7 purinoceptor;purinergic receptor P2X7
Recombinant Proteins
- Human
- Rat
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| P2RX7-1494H | Recombinant Human P2RX7, GST-tagged | E.coli | Human | GST | C-term-350aa | |
| P2RX7-3635H | Recombinant Human P2RX7 protein, His-tagged | E.coli | Human | His | 382-589 aa | |
| P2RX7-391H | Recombinant Human P2RX7 Protein, His-tagged | E.coli | Human | His | Ser47~Val334 | |
| P2RX7-1219H |
Active Recombinant Human P2RX7 Full Length Transmembrane protein(Nanodisc)
|
HEK293 | Human | Non | Full L. |
|
| P2RX7-4232R | Recombinant Rat P2RX7 Protein | Mammalian Cell | Rat | His |
|
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| P2RX7-9888Z | Recombinant Zebrafish P2RX7 | Mammalian Cell | Zebrafish | His |
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| P2RX7-3495HCL | Recombinant Human P2RX7 293 Cell Lysate | HEK293 | Human | Non |
|
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| P2RX7-3894R | Recombinant Rat P2RX7 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| P2RX7-3894R-B | Recombinant Rat P2RX7 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| P2RX7-390H | Recombinant Human P2RX7 Protein, GST-tagged | Wheat Germ | Human | GST | 1-595 |
|
| P2RX7-4779H | Recombinant Human P2RX7 Protein (Asp356-Tyr595), N-His tagged | E.coli | Human | His | Asp356-Tyr595 |
|
| P2RX7-6868HF | Recombinant Full Length Human P2RX7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 595 amino acids |
|
Involved Pathway
P2RX7 involved in several pathways and played different roles in them. We selected most pathways P2RX7 participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | Adcy4,PPP3CC,ADRa1A,PRKACBB,HTR2B,EGFRA,PPP3R2,AVPR1A,CAMK2A,PTGER1B |
| Neuroactive ligand-receptor interaction | P2RX5,TAAR12C,Gh,GPR50,PRP2,GRIK2,PPYR1,ADRB3B,PTGER4A,TAAR14J |
Protein Function
P2RX7 has several biochemical functions, for example, ATP binding,extracellular ATP-gated cation channel activity,lipopolysaccharide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX7 itself. We selected most functions P2RX7 had, and list some proteins which have the same functions with P2RX7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CDCA8,NAPRT1,ZNF136,SCN11A,MIER1,JPH2,EXOSC8,VAC14,NAIF1,DCTN4 |
| extracellular ATP-gated cation channel activity | P2RX4A,NNR,P2RX2,P2RX8,P2RX4B,P2RX6,P2RX3B,P2RX1,P2RX3,P2RX5 |
| receptor binding | CRAT,PTPRD,LAMA1,SERPINE2,Itga10&Itgb1,HFE2,AKAP9,WNT7A,FGF8A,CAPRIN2 |
| protein homodimerization activity | MCL1B,TCF3,UNC13A,MLL1,UPK1A,MIXL1,HMGCL,HINT2,TBC1D22A,MAOB |
| lipopolysaccharide binding | RNASE7,BPIFA2,SCARB1,TREM2,SPON2,PTAFR,TLR4,TLR2,TRIL,PSMB4 |
| purinergic nucleotide receptor activity | P2RX4B,P2RX6,P2RX1,P2RX5,P2RX4,P2RX3B,P2RX4A,NNR,P2RX2,P2RX3 |
| ATP binding | DDX25,RIPK3,UBE2A,ABCA4A,LARS2,ABCG2C,PAPD4,EPHB4,LMTK3,SPHK2 |
Interacting Protein
P2RX7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX7 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX7.
ABL1;NCK1;GRB2;CASK;TM9SF1;EFNB3
Resources
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References
- Bertelli, R; Di Donato, A; et al. LPS Nephropathy in Mice Is Ameliorated by IL-2 Independently of Regulatory T Cells Activity. PLOS ONE 9:-(2014).
- Furlan-Freguia, C; Marchese, P; et al. P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice. JOURNAL OF CLINICAL INVESTIGATION 121:2932-2944(2011).
Reviews
Q&As
To perform single channel functional measurements on the P2X7 protein, there are several requirements that need to be considered: 1. Purification of the P2X7 protein: The P2X7 protein needs to be purified to ensure that only the target protein is inserted into the artificial bilayer membrane for measurements. This typically involves expression and purification of the protein from a suitable expression system such as mammalian cells or bacteria. 2. Protein stability: The P2X7 protein needs to be stable in order to maintain its structure and function during the insertion process and measurements. Proper handling and storage conditions should be maintained to prevent protein degradation. 3. Protein concentration: The concentration of the P2X7 protein should be optimized for successful insertion into the artificial bilayer membrane. Too low of a concentration may result in insufficient protein insertion, while too high of a concentration may lead to non-specific binding or aggregation. Based on the above factors, we suppose P2RX7-1219H is a suitable protein for your application. This full length protein is very stable even at RT and its purity is greater than 90%. It is in lyophilized form and you can resolve it at your ideal concentration.
Based on your requests, we would like to recommend you choose our cell lysate which contains full-length P2RX7 protein. It is suitable for Western Blot assay.