OXCT1
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Official Full Name
3-oxoacid CoA transferase 1 -
Overview
This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. -
Synonyms
OXCT1;3-oxoacid CoA transferase 1;3 oxoacid CoA transferase , OXCT;succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial;SCOT;3 oxoacid CoA transferase 1;3-oxoacid-CoA transferase 1;EC 2.8.3.5;OTTHUMP00000120012;OTTHUMP00000221550;OXCT;Scot S;Scot-S;SCOT1_HUMAN;Somatic type succinyl CoA:3 oxoacid CoA transferase;Somatic-type succinyl-CoA:3-oxoacid-CoA-transferase;Succinyl CoA:3 ketoacid CoA transferase;Succinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial;Succinyl CoA:3 oxoacid CoA transferase;succinyl CoA:3-oxoacid CoA transferase;succinyl-CoA:3-ketoacid-CoA transferase;somatic-type succinyl CoA:3-oxoacid CoA-transferase
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- His
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
OXCT1 involved in several pathways and played different roles in them. We selected most pathways OXCT1 participated on our site, such as Synthesis and degradation of ketone bodies,Valine, leucine and isoleucine degradation,Butanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with OXCT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Butanoate metabolism | OXCT1B,ACADS,ECHS1,OXCT2,EHHADH,ACSM5,ACSM4,HADHAB,HADH,HMGCS1 |
| Valine, leucine and isoleucine degradation | ACAA1,HMGCL,AOX3,BCKDHB,ALDH6A1,ALDH1B1,ACSF3,AUH,AACS,ALDH9A1B |
| Synthesis and degradation of ketone bodies | OXCT2B,OXCT2,BDH2,ACAT2,HMGCL,HMGCLL1,ACAT1,OXCT2A,HMGCS1,BDH1 |
Protein Function
OXCT1 has several biochemical functions, for example, 3-oxoacid CoA-transferase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OXCT1 itself. We selected most functions OXCT1 had, and list some proteins which have the same functions with OXCT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TCF3,ERBB3,TIMM9,CEACAM5,GIMAP7,PRKG2,ACOT7,BAXB,NUDT16,PRPS1 |
| 3-oxoacid CoA-transferase activity | OXCT2,OXCT2A,OXCT2B,OXCT1B,OXCT1A |
Interacting Protein
OXCT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OXCT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of OXCT1.
TFCP2;PSEN1;NDUFV1;IQCB1;CLPP
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