NUP133
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Official Full Name
nucleoporin 133kDa -
Overview
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. -
Synonyms
NUP133;nucleoporin 133kDa;nucleoporin 133kD;nuclear pore complex protein Nup133;FLJ10814;133 kDa nucleoporin;hNUP 133;hNUP133;MGC21133;NU133_HUMAN;Nucleoporin NUP133;NUP 133;OTTHUMP00000061095
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- His&T7
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NUP133-1413H | Recombinant Human NUP133, GST-tagged | E.coli | Human | GST | C-term-300aa | |
| NUP133-12689Z | Recombinant Zebrafish NUP133 | Mammalian Cell | Zebrafish | His |
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| NUP133-1542H | Recombinant Human NUP133 protein, His & T7-tagged | E.coli | Human | His&T7 | Asp899~Asp1091 |
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| Nup133-1543M | Recombinant Mouse Nup133 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Leu36~His240 |
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| NUP133-3633HCL | Recombinant Human NUP133 293 Cell Lysate | HEK293 | Human | Non |
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| Nup133-4549M | Recombinant Mouse Nup133 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| NUP133-4982H | Recombinant Human NUP133 Protein (Asp899-Asp1091), N-His tagged | E.coli | Human | His | Asp899-Asp1091 |
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| NUP133-5338H | Recombinant Human NUP133 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
NUP133 involved in several pathways and played different roles in them. We selected most pathways NUP133 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUP133 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | NUP62,RPP38,THOC1,EIF2S2,SEC13,EIF4BA,XPO1,EIF5B,XPO5,EEF1A1L1 |
Protein Function
NUP133 has several biochemical functions, for example, nucleocytoplasmic transporter activity,protein binding,structural constituent of nuclear pore. Some of the functions are cooperated with other proteins, some of the functions could acted by NUP133 itself. We selected most functions NUP133 had, and list some proteins which have the same functions with NUP133. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | UBA6,C14orf118,INSIG2,HSPA9,CD8A,BSX,DYM,ARL2,FAM127C,GTPBP4 |
| nucleocytoplasmic transporter activity | NUP153,NUP54,TPRB,RBM22,NUP160,UPF3A,NUP35,NUP107,NUP214,NUPL1 |
| structural constituent of nuclear pore | NUP107,NDC1,NUP62CL,NUP54,NUP155,NUP93,NUP153,NUP85,NUP62L,TMEM33 |
Interacting Protein
NUP133 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUP133 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUP133.
NUP107;LRRK2;MYC;Nup98;Nup107;NUP153;AHCTF1
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References
- Dawson, TR; Lazarus, MD; et al. ER membrane-bending proteins are necessary for de novo nuclear pore formation. JOURNAL OF CELL BIOLOGY 184:659-675(2009).
- Harel, A; Orjalo, AV; et al. Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores. MOLECULAR CELL 11:853-864(2003).
